期刊
JOURNAL OF NEUROMUSCULAR DISEASES
卷 10, 期 2, 页码 185-197出版社
IOS PRESS
DOI: 10.3233/JND-221582
关键词
Neuromuscular diseases; muscular diseases; myositis; heart diseases
This study explores the effectiveness of a multimodality screening approach in detecting potentially reversible myocarditis in newly diagnosed patients with idiopathic inflammatory myopathy. The screening includes cardiac evaluation using biomarkers, electrocardiography, echocardiography, and cardiac magnetic resonance imaging. The study suggests that a diagnostic algorithm combining high-sensitivity cardiac troponins and cardiac magnetic resonance imaging may be effective in detecting myocarditis in adult patients with idiopathic inflammatory myopathy.
Background: Cardiac involvement in idiopathic inflammatory myopathy (IIM or myositis) is associated with an approximate 4% mortality, but standardised screening strategies are lacking. Objective: We explored a multimodality screening on potentially reversible cardiac involvement - i.e. active (peri)myocarditis - in newly diagnosed IIM. Methods: We included adult IIM patients from 2017 to 2020. At time of diagnosis, patients underwent cardiac evaluation including laboratory biomarkers, electrocardiography, echocardiography, and cardiac magnetic resonance imaging (CMR). Based on 2019 consensus criteria for myocarditis, an adjudication committee made diagnoses of definite, probable, possible or no (peri)myocarditis. We explored diagnostic values of sequentially added diagnostic modalities by Constructing Classification and Regression Tree (CART) analysis in patients with definite/probable versus no (peri) myocarditis. Results: We included 34 IIM patients, in whom diagnoses of definite (six, 18%), probable (two, 6%), possible (11, 32%), or no (peri)myocarditis (15, 44%) were adjudicated. CART-analysis showed high-sensitivity cardiac troponin T (cut-off value < 2.3 times the upper limit of normal (xULN)) ruled out (peri)myocarditis with a sensitivity of 88%, while high-sensitivity troponin I (cut-off value > 2.9 xULN for females and > 1.8 xULN for males) ruled in (peri)myocarditis with a specificity of 100%. Applying high-sensitivity cardiac troponins with these cut-off values in a diagnostic algorithm without and with a CMR to the total population of 34 patients demonstrated a diagnostic accuracy for a clear diagnosis of probable/definite or no (peri)myocarditis of 59% and 68%, respectively.Conclusions: A diagnostic algorithm for detection of (peri)myocarditis in adult IIM may consist of sequential testing with high-sensitivity cardiac troponins and CMR.
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