期刊
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
卷 78, 期 -, 页码 1244-+出版社
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S2056989022010842
关键词
benzothiazinones; azoxy compound; antituberculosis drugs; reaction mechanism; crystal structure
资金
- German Research Foundation (DFG)
The structure of a new compound was successfully synthesized and determined. X-ray crystallography revealed that the compound is composed of two benzothiazinone moieties linked by a Z-configured azoxy group, forming a densely packed herringbone pattern in the crystal.
(Z)-1,2-Bis[4-oxo-2-(piperidin-1-yl)-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-8-yl]diazene oxide, C28H24F6N6O3S2, was obtained and its structure determined while attempting to crystallize and structurally characterize 8-nitro-2-(piperidin-1-yl)-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one, a simplified analogue of the antituberculosis clinical drug candidate BTZ043. X-ray crystallography revealed the structure of the azoxy compound to be comprised of two benzothiazinone moieties linked by a Z-configured azoxy group in an almost coplanar arrangement. In the crystal, the molecules are densely packed, revealing a herringbone pattern.
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