期刊
JOURNAL OF DIABETES AND METABOLIC DISORDERS
卷 -, 期 -, 页码 -出版社
SPRINGER INT PUBL AG
DOI: 10.1007/s40200-022-01157-2
关键词
Diabetic neuropathic ulcer; Dose-response; Oxidative stress markers; Photobiomodulation therapy; Wound healing
资金
- Manipal Academy of Higher Education, Manipal
Photobiomodulation therapy is effective in treating diabetic neuropathic ulcers and improves oxidative stress. There is a strong dose-response relationship in the wound healing dynamics of the experimental groups treated with 4, 6, and 8 J/cm(2) dosages.
Purpose:Diabetic foot ulcers are reported to be the most expensive complications of diabetes, with high morbidity and mortality rates. If the necessary care is not provided for the wound to heal, the individual may end up amputating the affected feet. Photobiomodulation therapy is a promising non-pharmacological treatment option for wound healing. The objective of the present study is to establish a dose-response relationship between photobiomodulation therapy and oxidative stress markers in the healing dynamics of diabetic neuropathic ulcers in Wistar rats. Methodology:Diabetic neuropathy was induced in 126 Albino Wistar rats. An excisional wound of an area of 2cm(2) was made on the neuropathy-induced leg. Photobiomodulation therapy of dosages 4, 6, 8, 10, 12, and 15 J/cm(2) of wavelengths 655 and 808 nm was irradiated. The control group animals were kept un-irradiated. The outcome measures were assessed during wound healing's inflammatory, proliferative and remodelling phases. Results:In the experimental group, animals treated with photobiomodulation therapy at doses of 4, 6, and 8 J/cm(2) showed better wound healing dynamics. Photobiomodulation therapy modulated the reactive oxygen species and antioxidant levels, thereby improving the oxidative status of the wound. Conclusion:Photobiomodulation therapy of dosages 4, 6, and 8 J/cm(2) is effective and is a promising adjuvant modality in treating diabetic neuropathic ulcers. There was a strong dose-response relationship in the experimental groups treated with 4, 6 and 8 J/ cm(2).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据