期刊
CELLULAR IMMUNOLOGY
卷 295, 期 2, 页码 144-149出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2015.03.006
关键词
TSLP; Cancer; Metastasis; Tregs; Fibrosys
资金
- Zhejiang Provincial Merit-Based Postdoctoral Research Foundation of China
- Zhejiang Sports Administration Natural Science Foundation of China
Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine produced mainly by epithelial cells. Many studies indicate that TSLP contributes to promote T helper (Th) 2 immune responses which are associated with the pathogenesis of allergic inflammatory diseases. Base on the cross-talk between Th2 inflammation and cancers, we will highlight the role of TSLP in the progression of cancers in this review. TSLP is involved in the increasing prevalence of Tregs in the cancer microenvironment. Besides, TSLP has an important role in promoting the growth of vascular endothelial cells and angiogenesis, which could further promote the development and progression of cervical cancer. It gives the evidence that TSLP could induce EMT to promote cancer metastasis. In addition, TSLP could be detected in some fibroblasts and may play a role in the pathogenesis of non-allergic diseases characterized by a type 2 immune response and organ fibrosis. (C) 2015 Elsevier Inc. All rights reserved.
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