Enrichment patterns of intrinsic disorder in proteins

Intrinsically disordered regions in proteins have been shown to be important in protein function. However, not all proteins contain the same amount of intrinsic disorder. The variation in the levels of intrinsic disorder in different types of proteins has been extensively studied over the last two decades. It is now known that the levels of intrinsic disorder vary in proteins across organisms, functions, diseases, and cellular locations. This review consolidates the known trends in the abundance of intrinsic disorder identified in groups of proteins across varying conditions and functions. It also presents new data towards the understanding of intrinsic disorder in cell type-specific proteins.

Automated summary

Intrinsically disordered regions in proteins play an important role in protein function, but the levels of intrinsic disorder vary in different proteins. Extensive research has shown that the levels of intrinsic disorder can vary across organisms, functions, diseases, and cellular locations. This review summarizes the known trends in the abundance of intrinsic disorder in groups of proteins under different conditions and functions, and presents new data on intrinsic disorder in cell type-specific proteins.