期刊
MOLBANK
卷 2023, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/M1546
关键词
monoterpene; epoxide cycle opening; tertiary amine
Parkinson's disease is a progressive neurodegenerative disorder characterized by movement dysfunction. A new Prottremin derivative was synthesized by opening the epoxide ring with 1-(4-isopropylbenzyl)piperazine, with a product yield of 48% after purification.
Parkinson's disease (PD) is a progressive neurodegenerative disorder mainly characterized by movement dysfunction. Earlier, it was found that (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol (Prottremin) demonstrated antiparkinsonian activity in vivo on different animal models of PD. The paper presents synthesis of new Prottremin derivative, (1R,2R,6S)-2(4-(4-isopropylbenzyl)piperazin-1-yl)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-enol. The derivative was obtained by epoxide ring opening reaction with 1-(4-isopropylbenzyl)piperazine. The product yield was 48% after purification.
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