期刊
JOURNAL OF SURGICAL RESEARCH
卷 202, 期 1, 页码 225-234出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jss.2015.12.008
关键词
IAP; Sepsis; NEC; IBD; Metabolic syndrome; Intestinal microbiome; Bacterial translocation
类别
资金
- NCATS NIH HHS [UL1 TR000055] Funding Source: Medline
Over the past few years, there is increasing evidence implicating a novel role for Intestinal Alkaline Phosphatase (IAP) in mitigating inflammatory mediated disorders. IAP is an endogenous protein expressed by the intestinal epithelium that is believed to play a vital role in maintaining gut homeostasis. Loss of IAP expression or function is associated with increased intestinal inflammation, dysbiosis, bacterial translocation and subsequently systemic inflammation. As these events are a cornerstone of the pathophysiology of many diseases relevant to surgeons, we sought to review recent research in both animal and humans on IAP's physiologic function, mechanisms of action and current research in specific surgical diseases. (C) 2016 Elsevier Inc. All rights reserved.
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