期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 36, 期 5, 页码 669-682出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-015-0247-x
关键词
Hippocampal neuron; Porphyra yezoensis; Taurine; Neuronal development; Synaptogenesis; Neuroprotection
资金
- Global Healthcare Industry RIS Center, Korean Ministry of Knowledge Economy
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Korean Ministry of Science, ICT and future Planning [2015R1A2A2A01007104]
- National Research Foundation of Korea [2015R1A2A2A01007104] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The edible red alga Porphyra yezoensis is among the most popular marine algae and is of economic and medicinal importance. In the present study, the neurotrophic and neuroprotective activities of the ethanol extract of P. yezoensis (PYE) were investigated in primary cultures of hippocampal neurons. Results revealed that PYE significantly increased neurite outgrowth at an optimal concentration of 15 A mu g/mL. PYE dose-dependently increased viable cells, significantly accelerated the rate of neuronal differentiation in cultures, promoted axodendritic arborization, and eventually induced synaptogenesis. In addition to morphological development, PYE also promoted functional maturation as indicated by the staining of live cultures with FM 1-43. Moreover, PYE increased neuronal survivability, which was attributed to reduced apoptosis and its ROS scavenging activity. Taurine, a major organic acid in PYE (2.584/100 mg of dry PYE) promoted neurite outgrowth in a dose-dependent manner, and this promotion was suppressed by the taurine antagonist isethionic acid. The study indicates that PYE and its active component, taurine, facilitate neuronal development and maturation and have a neuroprotective effect.
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