期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 114, 期 5, 页码 602-606出版社
WILEY-BLACKWELL
DOI: 10.1002/jso.24382
关键词
gastric cancer; race; survival
Background and Objectives: The purpose of this study was to identify clinicopathologic factors associated with overall survival (OS) in early T stage gastric cancer in a Western population. Methods: Patients with stage T1 or T2 gastric or gastroesophageal adenocarcinoma who had undergone upfront gastrectomy from 1995 to 2013 were identified in an institutional database. Results: We identified 121 patients with pathologic stage T1 or T2 tumors (49 [41%] T1a; 49 [41%] T1b; and 23 [19%] T2) who underwent R0 resection without preoperative treatment. Of these, 53% were white, 9% African American, 17% Hispanic, and 22% Asian. The median follow-up was 5.7 years, and the 5-year OS rate was 89% (98%, 93%, and 66% for patients with T1a, T1b, and T2 tumors, respectively). Univariate analysis revealed a higher risk of death in patients with T2 tumors and those of African American race. On multivariate analysis, T2 stage was the only variable independently associated with OS (hazard ratio, 2.80; 95% confidence interval, 1.11-7.12; P = 0.03). Conclusion: In this study of a Western population of patients with T1 or T2 gastric cancer, T2 stage was associated with diminished OS, whereas nodal status and race were not. (C) 2016 Wiley Periodicals, Inc.
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