☆ 3.8 Review

Protocol, rationale and design of the PHOLLOW cross-sectional and retrospective chart review study to assess the prevalence and characterize the patient profile, clinical features and disease burden of type-2 low severe asthma in routine care settings in Greece

PNEUMON (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Respiratory System

Current unmet needs and potential solutions to uncontrolled asthma

William W. Busse et al.

Summary: Asthma patients often have poor asthma control, which not only affects the patients themselves but also burdens society. Solutions such as shared decision-making, good patient-clinician communication, self-management, multidisciplinary education, and new technology may help improve asthma control.

EUROPEAN RESPIRATORY REVIEW (2022)

添加到收藏夹

Article Respiratory System

Treatment options in type-2 low asthma

Timothy S. C. Hinks et al.

Summary: This article summarizes the characteristics, clinical features, and underlying pathobiological mechanisms of type-2 low asthma, discusses treatment options for this disease, and emphasizes the potential for development in this field.

EUROPEAN RESPIRATORY JOURNAL (2021)

添加到收藏夹

Review Biology

Molecular Targets for Biological Therapies of Severe Asthma: Focus on Benralizumab and Tezepelumab

Shih-Lung Cheng

Summary: Asthma is a heterogeneous respiratory disease characterized by reversible bronchial obstruction driven by complex pathobiological mechanisms. Biological therapies targeting specific molecules and signaling pathways have emerged as effective options for severe asthma management, providing personalized approaches for addressing the individual traits of asthma pathobiology.

LIFE-BASEL (2021)

添加到收藏夹

Article Critical Care Medicine

Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial

Liam G. Heaney et al.

Summary: The study compared a biomarker-based treatment adjustment strategy with a symptom-risk-based algorithm in severe asthma patients, finding that the biomarker strategy resulted in a higher proportion of patients reducing corticosteroid dose. Understanding patient non-compliance with treatment advice is an important area for future research. The prevalence of T2 biomarker-low severe asthma was found to be low.

LANCET RESPIRATORY MEDICINE (2021)

添加到收藏夹

Article Respiratory System

Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era

David J. Jackson et al.

Summary: The UK Severe Asthma Registry provides insights into a large cohort of patients referred to specialist severe asthma services in the UK. Despite the predominance of T2-high phenotypes, there are significant differences in T2-low patients, who often show evidence of prior corticosteroid exposure through elevated blood eosinophil counts.

THORAX (2021)

添加到收藏夹

Article Critical Care Medicine

Eosinophilic and Noneosinophilic Asthma An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort

Liam G. Heaney et al.

Summary: By analyzing patients with severe asthma from 11 countries globally, this study found the prevalence of eosinophilic and noneosinophilic asthma phenotypes, as well as the differences in characteristics between the two phenotypes, providing important insights for personalized treatment.

CHEST (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tezepelumab: A Potential New Biological Therapy for Severe Refractory Asthma

Corrado Pelaia et al.

Summary: TSLP is an innate cytokine that plays a key role in asthma pathogenesis, while tezepelumab is a fully human monoclonal antibody that prevents TSLP's interaction with receptors. Preliminary results indicate that tezepelumab has a good safety and efficacy profile in patients with severe, uncontrolled asthma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life

Fabio Luigi Massimo Ricciardolo et al.

Summary: This study demonstrates that phenotyping asthmatic patients using non-invasive parameters is feasible in clinical practice, which can help characterize the features of T2-low and T2-high asthma phenotypes.

BIOMEDICINES (2021)

添加到收藏夹

Review Allergy

Treatment approaches for the patient with T2 low asthma

Tara F. Carr

Summary: T2 low asthma affects approximately one-third to one-half of asthma patients, characterized by higher BMI, smoking/smoke exposure, steroid unresponsiveness, etc. Treatment approaches include inhalers, azithromycin, weight loss, and smoking cessation.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

添加到收藏夹

Review Respiratory System

Identification and treatment of T2-low asthma in the era of biologics

Chris Kyriakopoulos et al.

Summary: The management of T2-low asthma remains a challenge due to poor response to steroids and limited candidates for targeted biologic agents. Current research is focused on identifying biomarkers for T2-low asthma and targeting neutrophilic airway inflammation as a therapeutic approach. Therapeutic targets include molecules that restore corticosteroid sensitivity, bronchodilators, anti-inflammatory agents, and airway smooth muscle mass attenuation therapies.

ERJ OPEN RESEARCH (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

TSLP Inhibitors for Asthma: Current Status and Future Prospects

Maria Gabriella Matera et al.

DRUGS (2020)

添加到收藏夹

Review Respiratory System

Anti-alarmins in asthma: targeting the airway epithelium with next-generation biologics

Celeste M. Porsbjerg et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

添加到收藏夹

Article Respiratory System

DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma

Andrew Menzies-Gow et al.

RESPIRATORY RESEARCH (2020)

添加到收藏夹

Article Respiratory System

NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma

Andrew Menzies-Gow et al.

RESPIRATORY RESEARCH (2020)

添加到收藏夹

Review Respiratory System

Severe Asthma and Biological Therapy: When, Which, and for Whom

Paola Rogliani et al.

PULMONARY THERAPY (2020)

添加到收藏夹

Article Respiratory System

Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study

John Busby et al.

THORAX (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Tezepelumab: a novel biological therapy for the treatment of severe uncontrolled asthma

Giancarlo Marone et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2019)

添加到收藏夹

Review Medicine, General & Internal

Severe Eosinophilic Asthma

Agamemnon Bakakos et al.

JOURNAL OF CLINICAL MEDICINE (2019)

添加到收藏夹

Article Critical Care Medicine

A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma

Michael C. Peters et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

添加到收藏夹

Article Respiratory System

An algorithmic approach for the treatment of severe uncontrolled asthma

Eleftherios Zervas et al.

ERJ OPEN RESEARCH (2018)

添加到收藏夹

Article Medicine, General & Internal

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Theo Vos et al.

LANCET (2017)

添加到收藏夹

Review Allergy

Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications

D. Robinson et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2017)

添加到收藏夹

Review Respiratory System

T2-low asthma: current approach to diagnosis and therapy

Konstantinos Samitas et al.

CURRENT OPINION IN PULMONARY MEDICINE (2017)

添加到收藏夹

Review Allergy

Characterization of asthma endotypes: implications for therapy

Jeffrey R. Stokes et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2016)

添加到收藏夹

Review Respiratory System

Role of T2 inflammation biomarkers in severe asthma

Amit D. Parulekar et al.

CURRENT OPINION IN PULMONARY MEDICINE (2016)

添加到收藏夹

Article Allergy

Severe asthma: Epidemiology, burden of illness, and heterogeneity

David M. Lang

ALLERGY AND ASTHMA PROCEEDINGS (2015)

添加到收藏夹

Article Respiratory System

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Kian Fan Chung et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR)

F. Schleich et al.

RESPIRATORY MEDICINE (2014)

添加到收藏夹

Article Allergy

Development of the asthma control test: A survey for assessing asthma control

RA Nathan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.