期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 72, 期 24, 页码 4721-4757出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-2034-8
关键词
Autophagy; ATG; ULK; PtdIns3K; LC3
资金
- Deutsche Forschungsgemeinschaft [STO 864/3-1, STO 864/4-1]
- Research Committee of the Medical Faculty of the Heinrich-Heine-University Dusseldorf [58/2013]
- Dusseldorf School of Oncology
- Comprehensive Cancer Center Dusseldorf/Deutsche Krebshilfe
- Medical Faculty of the Heinrich-Heine-University Dusseldorf
Autophagy represents an intracellular degradation process which is involved in both cellular homeostasis and disease settings. In the last two decades, the molecular machinery governing this process has been characterized in detail. To date, several key factors regulating this intracellular degradation process have been identified. The so-called autophagy-related (ATG) genes and proteins are central to this process. However, several additional molecules contribute to the outcome of an autophagic response. Several review articles describing the molecular process of autophagy have been published in the recent past. In this review article we would like to add the most recent findings to this knowledge, and to give an overview of the network character of the autophagy signaling machinery.
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