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Editorial Material
Geriatrics & Gerontology
Roy L. Soiza et al.
Summary: The safety and efficacy of COVID-19 vaccines in older people are crucial for their success, but there is currently a lack of data. While some Phase III trials have made efforts to recruit older people, those with co-morbidities and frailty have still been largely excluded. Older people, their carers, and healthcare professionals will need to make decisions on vaccination acceptance based on limited evidence.
Editorial Material
Medicine, General & Internal
Johanna Chapin-Bardales et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Immunology
Birgit Weinberger
Summary: This review focuses on the age-related aspects of COVID-19 vaccines and vaccination strategies, summarizing data on immunogenicity, efficacy, and effectiveness of the four COVID-19 vaccines licensed in the US and/or Europe. The effectiveness of the vaccines declined over time, particularly against asymptomatic infection and mild disease, with the emergence of virus variants.
Article
Medicine, General & Internal
Eric J. Haas et al.
Summary: This study assessed the real-world effectiveness of the Pfizer-BioNTech mRNA COVID-19 vaccine BNT162b2 in Israel, showing high efficacy in preventing SARS-CoV-2 infections, hospitalizations, severe disease, and death. As vaccine coverage increased, there were marked declines in SARS-CoV-2 outcomes, indicating that COVID-19 vaccination can help control the pandemic.
Article
Infectious Diseases
Cristina Menni et al.
Summary: This study investigated the safety and effectiveness of the BNT162b2 and ChAdOx1 nCoV-19 vaccines in a UK community setting. The results showed that the frequencies of side effects from these vaccines were lower than reported in clinical trials, and a significant reduction in the risk of SARS-CoV-2 infection was observed starting at 12 days after vaccination.
LANCET INFECTIOUS DISEASES
(2021)
Article
Immunology
Velayudhan Mohan Kumar et al.
Summary: India has started a large-scale COVID-19 vaccination program, with four domestically developed vaccines already approved. The country has the capacity to meet its vaccination needs and has established sufficient manpower and cold-chain infrastructure for the initial phase. Additionally, India has taken urgent measures to expand vaccine manufacturing capacity and implemented an efficient digital system for vaccine administration.
Article
Biology
Alexander G. Mathioudakis et al.
Summary: The study compares the safety, tolerability, and reactogenicity of different COVID-19 vaccines among various recipient groups. Those who had a prior COVID-19 infection were found to have an increased risk of vaccination side effects, with mRNA vaccines causing milder systemic reactions but more local reactions compared to viral vector-based vaccines.
Article
Immunology
Aditya P. Desai et al.
Summary: The Pfizer-BioNTech and Moderna mRNA vaccines for COVID-19 are approved for emergency use in the US, with a rare reported incidence of anaphylaxis. Recipients with prior history of allergies and/or anaphylaxis have higher relative incidence of anaphylaxis following vaccination, providing valuable metrics for evidence-based decisions.
Review
Allergy
Matthew Greenhawt et al.
Summary: This study involved an international multidisciplinary group of experts to systematically investigate the incidence of anaphylaxis after SARS-CoV-2 vaccination and the accuracy of allergy testing tools. The research found a low incidence of anaphylaxis after SARS-CoV-2 vaccination and low sensitivity of polyethylene glycol skin testing, but high specificity. Recommendations were made for vaccination for individuals without a history of severe allergic reactions and shared decision-making with an allergy specialist for those with a history of severe allergic reactions. Further research is recommended to clarify the utility of testing in individuals potentially allergic to SARS-CoV-2 vaccines or their excipients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Respiratory System
Janmejaya Samal
Summary: The COVID-19 pandemic brought about a unique challenge with the infodemic of misinformation and disinformation, impacting individuals' behavior and vaccine uptake. Efforts are needed to counter this misinformation and alleviate the global pandemic.
EGYPTIAN JOURNAL OF BRONCHOLOGY
(2021)
Article
Medicine, General & Internal
Maheshi N. Ramasamy et al.
Editorial Material
Immunology
Rebecca E. Chandler
NATURE REVIEWS IMMUNOLOGY
(2020)
Article
Health Care Sciences & Services
Adriana Parrella et al.
BMC HEALTH SERVICES RESEARCH
(2013)