期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 73, 期 3, 页码 497-521出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-2072-2
关键词
Circadian; mRNA expression; Post-transcriptional regulation; Systems biology; Biostatistics
资金
- German Ministry of Science and Education (BMBF) [FKZ 0315899]
Circadian clocks synchronize organisms to the 24 h rhythms of the environment. These clocks persist under constant conditions, have their origin at the cellular level, and produce an output of rhythmic mRNA expression affecting thousands of transcripts in many mammalian cell types. Here, we review the charting of circadian output rhythms in mRNA expression, focusing on mammals. We emphasize the challenges in statistics, interpretation, and quantitative descriptions that such investigations have faced and continue to face, and outline remaining outstanding questions.
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