期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 73, 期 6, 页码 1237-1252出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-2120-y
关键词
Aging; Ageing; Caloric restriction; Geometric Framework; CPC diet; Dietary protein; Dietary carbohydrate
资金
- Aging and Alzheimers Research Institute
- NHMRC [571328, 1084267]
- Intramural Program of the National Institute on Aging, NIH
- National Health and Medical Research Council of Australia [1084267] Funding Source: NHMRC
Most research on nutritional effects on aging has focussed on the impact of manipulating single dietary factors such as total calorie intake or each of the macronutrients individually. More recent studies using a nutritional geometric approach called the Geometric Framework have facilitated an understanding of how aging is influenced across a landscape of diets that vary orthogonally in macronutrient and total energy content. Such studies have been performed using ad libitum feeding regimes, thus taking into account compensatory feeding responses that are inevitable in a non-constrained environment. Geometric Framework studies on insects and mice have revealed that diets low in protein and high in carbohydrates generate longest lifespans in ad libitum-fed animals while low total energy intake (caloric restriction by dietary dilution) has minimal effect. These conclusions are supported indirectly by observational studies in humans and a heterogeneous group of other types of interventional studies in insects and rodents. Due to compensatory feeding for protein dilution, low-protein, high-carbohydrate diets are often associated with increased food intake and body fat, a phenomenon called protein leverage. This could potentially be mitigated by supplementing these diets with interventions that influence body weight through physical activity and ambient temperature.
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