期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 72, 期 12, 页码 2377-2394出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-1872-8
关键词
Phylogenetic tree; Evolution; Lpar; ATX; LIPH; LIPI; Lipase
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that activates G protein-coupled LPA receptors to exert fundamental cellular functions. Six LPA receptor genes have been identified in vertebrates and are classified into two subfamilies, the endothelial differentiation genes (edg) and the non-edg family. Studies using genetically engineered mice, frogs, and zebrafish have demonstrated that LPA receptor-mediated signaling has biological, developmental, and pathophysiological functions. Computational analyses have also identified several amino acids (aa) critical for LPA recognition by human LPA receptors. This review focuses on the evolutionary aspects of LPA receptor-mediated signaling by comparing the aa sequences of vertebrate LPA receptors and LPA-producing enzymes; it also summarizes the LPA receptor-dependent effects commonly observed in mouse, frog, and fish.
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