期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 72, 期 5, 页码 857-868出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-014-1827-5
关键词
Laccase; Multi-copper oxidase; Cupredoxin; Trinuclear site; Mononuclear site; Reaction mechanism; Radiation damage; Crystal structure
资金
- Academy of Finland [256937, 263931]
- Academy of Finland (AKA) [256937, 263931, 256937, 263931] Funding Source: Academy of Finland (AKA)
Laccases are phenol oxidases that belong to the family of multi-copper oxidases and the superfamily of cupredoxins. A number of potential industrial applications for laccases have led to intensive structure-function studies and an increased amount of crystal structures has been solved. The objective of this review is to summarize and analyze available crystal structures of laccases. The experimental crystallographic data are now easily available from the websites and electron density maps can be used for the interpretation of the structural models. The crystal structures can give valuable insights into the functional mechanisms and may serve as the basis for the development of laccases for industrial applications.
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