Reversed-phase high-performance liquid chromatography analytical method development and validation for cefepime and sulbactam injection formulation assay: A quality by design approach

Article Biochemistry & Molecular Biology

Development and optimization of TPGS-based stealth liposome of doxorubicin using Box-Behnken design: characterization, hemocompatibility, and cytotoxicity evaluation in breast cancer cells

Balak Das Kurmi et al.

Summary: This study reports the development of a doxorubicin-loaded liposomal system coated with alpha-tocopherol polyethylene glycol 1000 succinate through a quality by design approach, showing promising anticancer and hemocompatibility potential. Optimization of formulation variables using systematic design of experiments resulted in nano-sized vesicles with favorable development parameters, and the inclusion of TPGS significantly improved the quality attributes of the liposomal formulations. The study concludes that quality by design optimization can be effectively utilized for obtaining liposomal formulations with desired attributes, and TPGS-coated liposomes may serve as an effective anticancer drug delivery vehicle.

JOURNAL OF LIPOSOME RESEARCH (2022)

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Review Chemistry, Analytical

A Mini-Review on Simultaneous Quantification of Active Pharmaceutical Ingredients By UV and Quality by Design Assisted HPLC Method

Geeta Rajput et al.

Summary: This review paper discusses the use of UV spectroscopy and HPLC for simultaneous estimation of multiple drug components, as well as the implementation of the QbD principle in method development and validation. The article provides valuable information on the development and application of HPLC methods for multicomponent analysis.

CURRENT ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Quality by design assisted high-performance liquid chromatography parameters for simultaneous estimation of simvastatin and fenofibrate

Geeta Rajput et al.

Summary: In this study, a reliable high-performance liquid chromatography method was developed using quality by design to simultaneously estimate the levels of simvastatin and fenofibrate. Through the optimization of chromatographic conditions and selection of optimal parameters, adequate baseline separation of the two drugs was achieved, improving the accuracy and repeatability of the analysis.

SEPARATION SCIENCE PLUS (2022)

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Article Biochemical Research Methods