期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 72, 期 17, 页码 3343-3353出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-1931-1
关键词
Toll-like receptor; Intestinal epithelium; Microbe; Traffic
资金
- National Institute of Health (NIH) [DK085194, DK093809, DK102934, CA178599]
- Charles and Johanna Busch Memorial Award [659160]
- NSF/BIO/IDBR [1353890]
- Rutgers University Faculty Research Grant [281708]
- New Jersey Commission on Cancer Research Postdoctoral Fellowship [DFHS13PPC016]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1353890] Funding Source: National Science Foundation
Toll-like receptors (TLRs) are membrane-bound microbial sensors that mediate important host-to-microbe responses. Cell biology aspects of TLR function have been intensively studied in professional immune cells, in particular the macrophages and dendritic cells, but not well explored in other specialized epithelial cell types. The adult intestinal epithelial cells are in close contact with trillions of enteric microbes and engage in lifelong immune surveillance. Mature intestinal epithelial cells, in contrast to immune cells, are highly polarized. Recent studies suggest that distinct mechanisms may govern TLR traffic and compartmentalization in these specialized epithelial cells to establish and maintain precise signaling of individual TLRs. We, using immune cells as references, discuss here the shared and/or unique molecular machineries used by intestinal epithelial cells to control TLR transport, localization, processing, activation, and signaling. A better understanding of these mechanisms will certainly generate important insights into both the mechanism and potential intervention of leading digestive disorders, in particular inflammatory bowel diseases.
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