Lack of a prompt normalization of immunological parameters is associated with long-term care and poor prognosis in COVID-19 affected patients receiving convalescent plasma: a single center experience

Article Medicine, General & Internal

Early Outpatient Treatment for Covid-19 with Convalescent Plasma

D. J. Sullivan et al.

Summary: This study evaluated the efficacy and safety of COVID-19 convalescent plasma in symptomatic adults and found that receiving convalescent plasma transfusion reduced the risk of hospitalization due to COVID-19-related reasons.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Letter Hematology

Operational protocol for donation of anti-COVID-19 convalescent plasma in Italy

Massimo Franchini et al.

VOX SANGUINIS (2021)

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Article Biochemistry & Molecular Biology

Characterizing the immune responses of those who survived or succumbed to COVID-19: Can immunological signatures predict outcome?

Ramin Sami et al.

Summary: The study found that changes in frequencies of certain immune cells and levels of specific immune factors could serve as potential predictors of mortality in COVID-19 patients. NK cell frequencies were significantly increased in patients who died during treatment, while monocyte numbers were elevated in both recovered and deceased patients. Th2, Th17, and Treg cell percentages were notably lower in deceased cases compared to healthy individuals and those who recovered.

CYTOKINE (2021)

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Review Virology

The interplay between the immune system and SARS-CoV-2 in COVID-19 patients

Sana Shabbir et al.

Summary: The global population has been significantly impacted by COVID-19, caused by SARS-CoV-2 with no effective treatment options available. Research has shown that patients exhibit active immune responses, potentially leading to issues like cytokine storm syndrome.

ARCHIVES OF VIROLOGY (2021)

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Review Biology

The Three Pillars of COVID-19 Convalescent Plasma Therapy

Massimo Franchini et al.

Summary: In this narrative review, the critical analysis focuses on three factors, known as pillars, crucial in determining the clinical effectiveness of this biologic therapy: convalescent plasma, the disease COVID-19, and the patients.

LIFE-BASEL (2021)

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Review Virology

COVID-19 Convalescent Plasma Is More than Neutralizing Antibodies: A Narrative Review of Potential Beneficial and Detrimental Co-Factors

Daniele Focosi et al.

Summary: In addition to specific antibodies, CCP may contain other factors that could have beneficial or detrimental effects on the treatment outcomes of COVID-19 patients, which warrants further investigation.

VIRUSES-BASEL (2021)

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Article Medicine, General & Internal