期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 13, 期 1, 页码 36-46出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2015.76
关键词
dengue virus; protective immunity; vaccine; yellow fever
类别
资金
- Shanghai Pasteur Health Research Foundation [Y359P41505]
Flaviviruses comprise approximately 70 closely related RNA viruses. These include several mosquito-borne pathogens, such as yellow fever virus (YFV), dengue virus (DENV), and Japanese encephalitis virus (JEV), which can cause significant human diseases and thus are of great medical importance. Vaccines against both YFV and JEV have been used successfully in humans for decades; however, the development of a DENV vaccine has encountered considerable obstacles. Here, we review the protective immune responses elicited by the vaccine against YFV to provide some insights into the development of a protective DENV vaccine.
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