Association of pro-inflammatory cytokines, inflammatory proteins with atherosclerosis index in obese male subjects

Objectives: Investigation the association of pro-inflammatory markers interleukin (IL)-1 beta and IL- 10 expression, serum levels of C-reactive protein (CRP), cyclooxygenase-2 (COX2), High-density lipoprotein (HDL), Apolipoprotein A1 (ApoA1), and ATP Binding Cassette Subfamily A Member 1 (ABCA1) inflammatory proteins with atherosclerosis index (homocysteine) in normal-weight and obese male subjects. Methods: 59 males including 30 obese (Body mass index (BMI) of >= 30 kg/m(2)) and 29 normal-weight (BMI of 18.5-24.9 kg/m(2)) were joined to this study. Plasma levels of IL-1 beta and IL-10 (pg/mL), CRP (pg/mL), COX-2 (ng/mL), APOA1 (mg/dL), ABCA1 (ng/mL), HDL, Cholesterol, and Triglyceride (TG) (mg/dL), and homocysteine (mu mol/L) was measured. Association of these biomarkers with homocysteine was determined. Results: Obese subjects had higher serum levels of IL10, IL1 beta, CRP, COX-2, TG, and cholesterol concentrations (all p < 0.05 except IL-10 and cholesterol) and low levels of HDL, APOA1, and ABCA1 (non-significant differences) in comparison to normal-weight group. Homocysteine levels were high in obese men with no significant differences between the two groups. In obese subjects, homocysteine had a significant inverse correlation with APOA1, ABCA1, and HDL, and a strong and moderate positive correlation was found with CRP and TG levels, respectively. Conclusions: High level of homocysteine and its correlation with inflammation proteins and markers in obese subjects appear to be contributed with atherosclerosis development.

Automated summary

This study investigated the association of pro-inflammatory markers and inflammatory proteins with atherosclerosis index in normal-weight and obese male subjects. The results showed that obese subjects had higher levels of IL-10, IL-1β, CRP, COX-2, TG, and cholesterol, and lower levels of HDL, ApoA1, and ABCA1 compared to normal-weight individuals. Homocysteine levels were high in obese men and had significant correlations with inflammation proteins and markers.