3.8 Editorial Material

NAFLD in Indians: A Myopic Yet Alarming Perspective

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Article Gastroenterology & Hepatology

Incidence and Predictors of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease

Shalimar et al.

Summary: This study aimed to assess the incidence and predictors of liver-related events (LREs) and mortality in nonalcoholic fatty liver disease (NAFLD) patients. The results showed differences in the incidence of LRE and mortality among patients categorized as noncirrhosis (NC), compensated cirrhosis (CC), and decompensated cirrhosis (DC). Diabetes was associated with poor outcomes in NC NAFLD. Age, hypertension, and DC were independent predictors of poor outcomes.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2023)

Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort

Tracey G. Simon et al.

Summary: This study demonstrated that patients with biopsy-proven NAFLD have a significantly higher risk of major adverse cardiovascular events, including ischemic heart disease, stroke, congestive heart failure, and cardiovascular mortality, compared to matched population controls. The risk of such events increases progressively with worsening NAFLD severity.
Article Gastroenterology & Hepatology

Clinical course of non-alcoholic fatty liver disease and the implications for clinical trial design

Alina M. Allen et al.

Summary: The study investigated the risk and progression of NAFLD in a population-based cohort over 23 years, finding that compensated cirrhosis has a certain risk of progression, requiring large sample sizes and long-term follow-up to detect therapeutic effects.

JOURNAL OF HEPATOLOGY (2022)

Editorial Material Medicine, General & Internal

Nonalcoholic Steatohepatitis - Opportunities and Challenges

Guadalupe Garcia-Tsao

Summary: NASH has become the main cause of cirrhosis and liver transplantation, unlike hepatitis C which is a liver-specific disorder. It is a complex metabolic disorder that requires finding alternative therapies and defining response to treatment, with diagnosis established through liver biopsy samples.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease

Arun J. Sanyal et al.

Summary: In this study involving patients with nonalcoholic fatty liver disease, advanced fibrosis stages F3 and F4 were associated with increased risks of liver-related complications and death over a median of 4 years of follow-up. Advanced fibrosis was also related to an increased incidence of liver decompensation events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Gastroenterology & Hepatology

Advanced fibrosis is associated with incident cardiovascular disease in patients with non-alcoholic fatty liver disease

Jacqueline B. Henson et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2020)

Review Gastroenterology & Hepatology

Treatment of non-alcoholic fatty liver disease - Current perspectives

Anshuman Elhence et al.

INDIAN JOURNAL OF GASTROENTEROLOGY (2020)

Article Medicine, General & Internal

Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease

David E. Kleiner et al.

JAMA NETWORK OPEN (2019)

Article Pharmacology & Pharmacy

Natural history of diseases: Statistical designs and issues

Nicholas P. Jewell

CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)

Article Gastroenterology & Hepatology

The Natural History of Non-Alcoholic Fatty Liver Disease

Stephen Caldwell et al.

DIGESTIVE DISEASES (2010)

Review Gastroenterology & Hepatology

Epidemiology and Natural History of Non-Alcoholic Steatohepatitis

Curtis K. Argo et al.

CLINICS IN LIVER DISEASE (2009)

Article Gastroenterology & Hepatology

Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis

Curtis K. Argo et al.

JOURNAL OF HEPATOLOGY (2009)

Review Gastroenterology & Hepatology

Cryptogenic cirrhosis and NAFLD: Are they related?

A Maheshwari et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)