期刊
CELL STEM CELL
卷 17, 期 3, 页码 260-271出版社
CELL PRESS
DOI: 10.1016/j.stem.2015.08.014
关键词
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资金
- NIH [R01-CA129765-06A1, R01-CA101860-06]
- Breast Cancer Research Foundation
- Komen For Cure Foundation
- Alfred Taubman Research Institute
- Dompe Pharmaceuticals
- MedImmune
- Cormorant Pharmaceuticals
Cellular heterogeneity represents one of the greatest challenges in cancer therapeutics. In many malignancies, this heterogeneity is generated during tumor evolution through a combination of genetic alterations and epigenetic events that recapitulate normal developmental processes including stem cell self-renewal and differentiation. Many, if not most, tumors display similar hierarchal organization, at the apex of which are stem-like cells'' that drive tumor growth, mediate metastasis, and contribute to treatment resistance. Using breast cancer as a model, we discuss how an improved understanding of tumor cellular heterogeneity and plasticity may lead to development of more effective therapeutic strategies.
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