期刊
CELL STEM CELL
卷 16, 期 2, 页码 119-134出版社
CELL PRESS
DOI: 10.1016/j.stem.2015.01.013
关键词
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资金
- National Basic Research Program of China (973 Program) [2012CB966401]
- National Natural Science Foundation of China [91310305]
- Ministry of Science and Technology [2013DFG30680]
- Key New Drug Creation and Manufacturing Program [2011ZX09102-010-03]
- Ministry of Education of China (111 Project)
The direct lineage reprogramming of one specialized cell type into another using defined factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of differentiated cells. With the rapid increase in cell types generated through direct conversion in recent years, this strategy has become a promising approach for producing functional cells. Here, we review recent advances in lineage reprogramming, including the identification of novel reprogramming factors, underlying molecular mechanisms, strategies for generating functionally mature cells, and assays for characterizing induced cells. We also discuss progress toward the application of lineage reprogramming and the major future challenges for this strategy.
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