Preparation and application of calcium phosphate nanocarriers in drug delivery

Calcium phosphate nanoparticles represent promising materials for drug delivery because of its favorable prop-erties, including biocompatibility, biodegradability and strong affinity for binding to nucleic acids (pDNA, siRNA, miRNA, etc.) and therapeutic drugs (cisplatin, carboplatin, paclitaxel, gefitinib, doxorubicin, etc.). Various stra-tegies to prepare the size-controllable, stable, targeting and pH-responsive CaP nanocarriers have been extensively developed as the potential candidates in clinic. This review discusses the mostly recent developments in the design of calcium phosphate nanocarriers as drug delivery systems and therapeutic agents. Additionally, the advantage is unquestionably demonstrated and the obstacles are thoroughly examined in order to overcome future clinical issues.

Automated summary

Calcium phosphate nanoparticles have favorable properties for drug delivery and have been extensively developed in terms of design and preparation. This review discusses the recent developments in the use of calcium phosphate nanocarriers as drug delivery systems and therapeutic agents.