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The influence of flip-flop in population pharmacokinetic analyses

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2023)

Metformin doses to ensure efficacy and safety in patients with reduced kidney function

Isabelle H. S. Kuan et al.

Summary: Our study developed a dosing strategy for metformin based on kidney function to optimize efficacy and safety. By analyzing data from two studies and using simulations from a pharmacokinetic model, we found a strong relationship between metformin clearance and estimated kidney function. The probability of exceeding safety targets for plasma metformin concentration was generally low, supporting cautious use of metformin at appropriate doses in patients with impaired kidney function.

PLOS ONE (2021)

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Article Pharmacology & Pharmacy

Flip-Flop Phenomenon in Epidural Sufentanil Pharmacokinetics: A Population Study in Children and Infants

Agnieszka Borsuk et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2017)

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Article Urology & Nephrology

Extending Metformin Use in Diabetic Kidney Disease: A Pharmacokinetic Study in Stage 4 Diabetic Nephropathy

Ajith Munasinghe Dissanayake et al.

KIDNEY INTERNATIONAL REPORTS (2017)

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Article Pharmacology & Pharmacy

Population pharmacogenetic pharmacokinetic modeling for flip-flop phenomenon of enteric-coated mycophenolate sodium in kidney transplant recipients

Nayoung Han et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2014)

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Article Pharmacology & Pharmacy

Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate

Maria Cusato et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2011)

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The influence of flip-flop in population pharmacokinetic analyses

相关参考文献

Metformin doses to ensure efficacy and safety in patients with reduced kidney function

Flip-Flop Phenomenon in Epidural Sufentanil Pharmacokinetics: A Population Study in Children and Infants

Extending Metformin Use in Diabetic Kidney Disease: A Pharmacokinetic Study in Stage 4 Diabetic Nephropathy

Population pharmacogenetic pharmacokinetic modeling for flip-flop phenomenon of enteric-coated mycophenolate sodium in kidney transplant recipients

Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate

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