The influence of flip-flop in population pharmacokinetic analyses

Flip-flop is a term used to describe the scenario where the rate constants for multiexponential models appear to be switched. However, in reality, it is a permutation of the rank order of the parameter values. In this perspective, we revisit flip-flop pharmacokinetics and discuss its influence in population pharmacokinetic analyses.

Automated summary

Flip-flop is a term used to describe the situation where rate constants in multiexponential models appear to be switched, but it is actually a permutation of parameter values' rank order. This article revisits flip-flop pharmacokinetics and discusses its influence in population pharmacokinetic analyses.