Indocyanine Green-Conjugated Superparamagnetic Iron Oxide Nanoworm for Multimodality Breast Cancer Imaging

Breast cancer is the leading cause of cancer-associated deaths among women. Techniques for non-invasive breast cancer detection and imaging are urgently needed. Multimodality breast cancer imaging is attractive since it can integrate advantages from several modalities, enabling more accurate cancer detection. In order to accomplish this, indocyanine green (ICG)-conjugated superparamagnetic iron oxide nanoworm (NW-ICG) has been synthesized as a contrast agent. When evaluated in a spontaneous mouse breast cancer model, NW-ICG gave a large tumor to normal tissue contrasts in multiple imaging modalities including magnetic particle imaging, near-infrared fluorescence imaging, and photoacoustic imaging, providing more comprehensive detection and imaging of breast cancer. Thus, NW-ICGs are an attractive platform for non-invasive breast cancer diagnosis.

Automated summary

Breast cancer is a major cause of cancer-related deaths in women, and there is an urgent need for non-invasive detection and imaging techniques. Multimodality breast cancer imaging, using indocyanine green-conjugated superparamagnetic iron oxide nanoworms, shows promising results in providing more accurate cancer detection and imaging. The nanoworms offer large tumor to normal tissue contrasts in multiple imaging modalities, making them an attractive platform for non-invasive breast cancer diagnosis.