期刊
CELL STEM CELL
卷 17, 期 5, 页码 624-634出版社
CELL PRESS
DOI: 10.1016/j.stem.2015.08.002
关键词
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资金
- Canadian Institute of Health Research (CIHR) [224002]
- Ontario Research Fund Global Leadership Round in Genomics and Life Sciences (GL2) Stem Cell Network [9/5254 (TR3)]
- CIHR [MOP 1025, MOP 126198]
- Canadian Heart and Stroke Foundation
Reactive astrocytes (RAs) have been reported to convert to multipotent neural stem cells (NSCs) capable of neurosphere (NS) formation and multiline-age differentiation in vitro. Using genetic tagging, we determined that subventricular zone (SVZ) NSCs give rise to NSs derived from the stroke-injured cortex. We demonstrate that these cells can be isolated from the cortex in two different models of stroke and from different stroke-lesioned cortical regions. Interestingly, SVZ NSCs give rise to a subpopulation of RAs in the cortex that contribute to astrogliosis and scar formation. Last, we show that these SVZ derived RAs can be converted to neurons in vivo by forced expression of Ascl1. Identifying the contribution of cells originating from the SVZ to injury repair has implications for neural regeneration strategies.
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