期刊
BIOLOGIA FUTURA
卷 73, 期 4, 页码 427-439出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s42977-022-00138-z
关键词
Functional diversification; Heat shock factors; Heat shock proteins; Heat shock response; Molecular evolution
类别
资金
- Eotvos Lorand University
- National Research Development and Innovation Office (NKFIH) through the OTKA Grant [FK 131944]
- ELKH-ELTE Genetics Research Group [01062]
- New National Excellence Program of the Ministry of Innovation and Technology from the source of the National Research, Development and Innovation Fund [UNKP-21-3]
Heat shock transcription factors (HSFs) are crucial for protein homeostasis and are involved in various biological processes and diseases. The function of HSF family members is not fully understood, but important regulatory mechanisms have been identified.
Heat shock transcription factors (HSFs) are widely known as master regulators of the heat shock response. In invertebrates, a single heat shock factor, HSF1, is responsible for the maintenance of protein homeostasis. In vertebrates, seven members of the HSF family have been identified, namely HSF1, HSF2, HSF3, HSF4, HSF5, HSFX, and HSFY, of which HSF1 and HSF2 are clearly associated with heat shock response, while HSF4 is involved in development. Other members of the family have not yet been studied as extensively. Besides their role in cellular proteostasis, HSFs influence a plethora of biological processes such as aging, development, cell proliferation, and cell differentiation, and they are implicated in several pathologies such as neurodegeneration and cancer. This is achieved by regulating the expression of a great variety of genes including chaperones. Here, we review our current knowledge on the function of HSF family members and important aspects that made possible the functional diversification of HSFs.
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