Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases

The vascular system of the prenatal brain is crucial for the development of the central nervous system. Communication between vessels and neural cells is bidirectional, and dysfunctional communication can lead to neurodevelopmental diseases. In the present review, we introduce neurodevelopmental and neuropsychiatric diseases potentially caused by disturbances in the neurovascular system and discuss candidate genes responsible for neurovascular system impairments. In contrast to diseases that can manifest during the developing stage, we have also summarized the disturbances of the neurovascular system in neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Furthermore, we discussed the role of abnormal vascularization and dysfunctional vessels in the development of neurovascular-related diseases.

Automated summary

The prenatal brain's vascular system is crucial for central nervous system development, and dysfunctional communication between vessels and neural cells can lead to neurodevelopmental diseases. This review introduces neurodevelopmental and neuropsychiatric diseases potentially caused by neurovascular system disturbances and discusses candidate genes responsible for these impairments. In addition to diseases that can manifest during development, the review also summarizes the disturbances of the neurovascular system in neurodegenerative diseases such as Alzheimer's and Parkinson's. The role of abnormal vascularization and dysfunctional vessels in the development of neurovascular-related diseases is also discussed.