Design and Preparation of Sensing Surfaces for Capacitive Biodetection

Despite their high sensitivity and their suitability for miniaturization, biosensors are still limited for clinical applications due to the lack of reproducibility and specificity of their detection performance. The design and preparation of sensing surfaces are suspected to be a cause of these limitations. Here, we first present an updated overview of the current state of use of capacitive biosensors in a medical context. Then, we summarize the encountered strategies for the fabrication of capacitive biosensing surfaces. Finally, we describe the characteristics which govern the performance of the sensing surfaces, along with recent developments that were suggested to overcome their main current limitations.

Automated summary

Despite their high sensitivity and miniaturization potential, the reproducibility and specificity of biosensors are still limited for clinical use. This article provides an updated overview of capacitive biosensors in medical applications and summarizes the strategies for fabricating sensing surfaces. It also discusses the characteristics governing the performance of sensing surfaces and recent developments to overcome their current limitations.