4.7 Article

Sample-to-Answer Immuno-Magnetic Assay Using Thermally Responsive Alkane Partitions

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BIOSENSORS-BASEL
卷 12, 期 11, 页码 -

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MDPI
DOI: 10.3390/bios12111030

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point-of-care; magnetofluidics; COVID-19

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To combat pandemics, rapid point-of-care diagnostics are needed to detect biomarkers in whole blood. A recent development called thermally responsive alkane partitions (TRAPs) enables sample-to-answer detection of SARS-CoV-2 antibodies in whole blood samples, with a limit of detection well below the clinically relevant threshold. This method can be used to track the progression of future pandemics and improve clinical and societal response.
To combat pandemics, there is a need for rapid point-of-care diagnostics to identify infected patients and to track the spread of the disease. While recent progress has been made in response to COVID-19, there continues to be a need for point-of-care diagnostics capable of detecting biomarkers-such as antibodies-in whole blood. We have recently reported the development of thermally responsive alkane partitions (TRAPs) for the automation of point-of-care immuno-magnetic assays. Here, we demonstrate the use of TRAPs to enable sample-to-answer detection of antibodies against the SARS-CoV-2 virus in whole blood samples. We report a limit of detection of 84 pg/mL, well below the clinically relevant threshold. We anticipate that the TRAP-enabled sample-to-answer immunoassay can be used to track the progression of future pandemics, leading to a more informed and robust clinical and societal response.

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