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Poisoning Regulation, Research, Health, and the Environment: The Glyphosate-Based Herbicides Case in Canada

TOXICS (2023)

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Article Engineering, Environmental

Outside the Safe Operating Space of the Planetary Boundary for Novel Entities

Linn Persson et al.

Summary: This article suggests that the safe operating space of the planetary boundary for novel entities is exceeded due to the increasing production and releases exceeding the global capacity for assessment and monitoring. Plastic pollution is highlighted as a major concern. The article presents an impact pathway from the production of novel entities to their impacts on Earth system processes and proposes several criteria for control variables. Urgent action is recommended to reduce the harm associated with exceeding the boundary by reducing the production and releases of novel entities.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

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Article Environmental Sciences

Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Sante cohort

Pauline Rebouillat et al.

Summary: The study revealed associations between dietary pesticide exposure and Type 2 Diabetes risk, with different effects depending on the types of pesticide mixture, and individuals with high dietary quality may have a lower risk.

ENVIRONMENTAL HEALTH (2022)

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Article Environmental Sciences

Killing two birds with one stone: Pregnancy is a sensitive window for endocrine effects on both the mother and the fetus

Isabelle Plante et al.

Summary: Pregnancy involves significant physiological and psychological changes in the mother to meet the needs of the growing fetus, with potential long-term impacts on health for both mother and baby. Dysregulation of placental function may lead to increased risk of chronic diseases for the fetus later in life.

ENVIRONMENTAL RESEARCH (2022)

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Article Environmental Sciences

Glyphosate-based herbicide induces long-lasting impairment in neuronal and glial differentiation

Lua Reis et al.

Summary: This study evaluated the long-term effects of subcytotoxic concentrations of GBH and GLY on the differentiation of human neuroepithelial stem cells (NES). It was found that GBH induced abnormal cellular differentiation, including immature neuronal profiles and a shift towards glial cell fate. These effects were associated with dysregulation of key genes involved in neurogenesis.

ENVIRONMENTAL TOXICOLOGY (2022)

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Review Biochemistry & Molecular Biology

Toxic Effects of Glyphosate on the Nervous System: A Systematic Review

Carmen Costas-Ferreira et al.

Summary: Glyphosate exposure can lead to neurotoxic effects such as altered cell development, disrupted neurotransmission, oxidative stress, neuroinflammation, and mitochondrial dysfunction, resulting in neuronal death and behavioral abnormalities.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biology

Does Glyphosate Affect the Human Microbiota?

Pere Puigbo et al.

Summary: Glyphosate, the most widely used agrochemical, was previously considered safe for human microbiota due to the absence of the target enzyme, but recent studies have shown potential risks to human microbiome. Further research is needed to determine the effects of glyphosate on healthy human microbiota.

LIFE-BASEL (2022)

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Article Endocrinology & Metabolism

Thyroid Cancer and Pesticide Use in a Central California Agricultural Area: A Case Control Study

Negar Omidakhsh et al.

Summary: This study provides evidence that residential pesticide exposure from agricultural applications is associated with an increased risk of thyroid cancer.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Article Food Science & Technology

The surfactant co-formulant POEA in the glyphosate-based herbicide RangerPro but not glyphosate alone causes necrosis in Caco-2 and HepG2 human cell lines and ER stress in the ToxTracker assay

Robin Mesnage et al.

Summary: The co-formulant POE-15 tallow amine (POE-15) and the active ingredient glyphosate in herbicides have been found to be cytotoxic, causing cell necrosis and oxidative stress. The study highlights the importance of comprehensive testing of both co-formulants and active ingredients of commercial pesticides to ensure better regulation and protection of public health and the environment.

FOOD AND CHEMICAL TOXICOLOGY (2022)

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Article Environmental Sciences

A planetary boundary for green water

Lan Wang-Erlandsson et al.

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NATURE REVIEWS EARTH & ENVIRONMENT (2022)

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Article Management

Suborning science for profit: Monsanto, glyphosate, and private science research misconduct

Leland Glenna et al.

Summary: The study revealed a private firm's efforts to distort the scientific peer-review process, engage in ghostwriting, and influence editorial decisions in order to manipulate the regulatory process and continue selling a potentially dangerous product. These findings have implications for the integrity of scientific peer review and public trust in science.

RESEARCH POLICY (2021)

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Article Environmental Sciences

Cancer incidence in agricultural workers: Findings from an international consortium of agricultural cohort studies (AGRICOH)

Kayo Togawa et al.

Summary: This study evaluated cancer incidence in male and female agricultural workers in an international consortium, AGRICOH, compared to their respective general populations. The results showed that agricultural workers have a lower risk of various cancers, but an elevated risk of prostate cancer, multiple myeloma (female), and melanoma of skin (female). There were significant variations in cancer risks between different cohorts.

ENVIRONMENT INTERNATIONAL (2021)

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Article Green & Sustainable Science & Technology

Can Glyphosate-Based Herbicides Contribute to Sustainable Agriculture?

Sheldon Krimsky

Summary: This paper investigates whether glyphosate-based herbicides (GBHs) are consistent with sustainable agriculture goals. Through an in-depth examination of scholarly literature, it concludes that GBHs do not align with the goals of agricultural sustainability.

SUSTAINABILITY (2021)

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Review Cell Biology

Review: Mechanisms of Glyphosate and Glyphosate-Based Herbicides Action in Female and Male Fertility in Humans and Animal Models

Loise Serra et al.

Summary: This review discusses the effects of glyphosate and glyphosate-based herbicides on reproductive functions and endocrine disruption, mainly by interfering with the hypothalamic-pituitary-gonadal axis in males and females, potentially leading to changes in cell viability and proliferation. The presence of formulants in GBHs makes them more toxic than glyphosate alone.

CELLS (2021)

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Article Geosciences, Multidisciplinary

Risk of pesticide pollution at the global scale

Fiona H. M. Tang et al.

Summary: Pesticides are widely used in agriculture to protect food production but also pose risks to water quality, biodiversity, and human health. A global study found that 64% of agricultural land worldwide is at risk of pesticide pollution, with 31% at high risk, particularly in areas with high biodiversity and water scarcity. High-concern regions such as South Africa, China, India, Australia, and Argentina were identified as facing high pesticide pollution risk, high biodiversity, and water scarcity issues.

NATURE GEOSCIENCE (2021)

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Article Toxicology

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Gilles-Eric Seralini et al.

Summary: Endocrine disruption and endocrine disruptors, established as scientific concepts in 1995, have been shown to impact the nervous system. Research indicates that approximately 80% of endocrine disruptors operate through mechanisms beyond the thyroid. This suggests a new concept of endocrine and nervous disruptors collectively referred to as ENDs, which share similarities with spam in electronic communications technologies.

TOXICOLOGY REPORTS (2021)

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Review Environmental Sciences

A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

Christopher J. Portier

ENVIRONMENTAL HEALTH (2020)

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Review Medicine, General & Internal

Mechanisms for addressing and managing the influence of corporations on public health policy, research and practice: a scoping review

Melissa Mialon et al.

BMJ OPEN (2020)

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Review Public, Environmental & Occupational Health

The global distribution of acute unintentional pesticide poisoning: estimations based on a systematic review

Wolfgang Boedeker et al.

BMC PUBLIC HEALTH (2020)

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Review Biotechnology & Applied Microbiology

Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: A meta-analysis and supporting evidence

Luoping Zhang et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2019)

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Article Medicine, General & Internal

Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study

Ondine S. von Ehrenstein et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Article Endocrinology & Metabolism

Glyphosate and glyphosate-based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome

Julie Dechartres et al.

JOURNAL OF NEUROENDOCRINOLOGY (2019)

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Article Public, Environmental & Occupational Health

Pesticide use in agriculture and Parkinson's disease in the AGRICAN cohort study

Camille Pouchieu et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2018)

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Article Health Care Sciences & Services

Roundup litigation discovery documents: implications for public health and journal ethics

Sheldon Krimsky et al.

JOURNAL OF PUBLIC HEALTH POLICY (2018)

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Article Multidisciplinary Sciences

Glyphosate perturbs the gut microbiota of honey bees

Erick V. S. Motta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Health Care Sciences & Services

Monsanto, PCBs, and the creation of a world-wide ecological problem

Gerald Markowitz et al.

JOURNAL OF PUBLIC HEALTH POLICY (2018)

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Article Public, Environmental & Occupational Health

The Monsanto Papers: Poisoning the scientific well

Leemon B. McHenry

INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE (2018)

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Article Public, Environmental & Occupational Health

The Production of Corporate Research to Manufacture Doubt About the Health Hazards of Products: An Overview of the Exponent Bakelite® Simulation Study

David Egilman

NEW SOLUTIONS-A JOURNAL OF ENVIRONMENTAL AND OCCUPATIONAL HEALTH POLICY (2018)

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Article Toxicology

Toxicity of formulants and heavy metals in glyphosate-based herbicides and other pesticides

N. Defarge et al.

TOXICOLOGY REPORTS (2018)

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Review Public, Environmental & Occupational Health

Parkinson's disease and occupational exposures: a systematic literature review and meta-analyses

Lars-Gunnar Gunnarsson et al.

SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH (2017)

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Review Substance Abuse

How does the alcohol industry attempt to influence marketing regulations? A systematic review

Emily Savell et al.

ADDICTION (2016)

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Review Environmental Sciences

Environmental factors in the development of autism spectrum disorders

L. A. Sealey et al.

ENVIRONMENT INTERNATIONAL (2016)

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Article Endocrinology & Metabolism

Estimating Burden and Disease Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union

Leonardo Trasande et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

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Article Multidisciplinary Sciences

Planetary boundaries: Guiding human development on a changing planet

Will Steffen et al.

SCIENCE (2015)

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Review Multidisciplinary Sciences

How Does the Tobacco Industry Attempt to Influence Marketing Regulations? A Systematic Review

Emily Savell et al.

PLOS ONE (2014)

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Article Biotechnology & Applied Microbiology

Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles

Robin Mesnage et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Article Environmental Sciences

Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize

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Environmental Sciences Europe (2014)

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Article Ethics

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JOURNAL OF LAW MEDICINE & ETHICS (2013)

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Article Public, Environmental & Occupational Health

Parkinson's disease risk from ambient exposure to pesticides

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EUROPEAN JOURNAL OF EPIDEMIOLOGY (2011)

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Article Social Issues

Corporate strategy, corporate capture: Food and alcohol industry lobbying and public health

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CRITICAL SOCIAL POLICY (2010)

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Article Environmental Sciences

Birth defects, season of conception, and sex of children born to pesticide applicators living in the Red River Valley of Minnesota, USA

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ENVIRONMENTAL HEALTH PERSPECTIVES (2002)

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