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Article
Biochemistry & Molecular Biology
Ali Ghorbani Ranjbary et al.
Summary: This study investigated the induction of apoptosis in colon cancer cells by Fe3O4 MNPs and its mechanism. The results showed that Fe3O4 MNPs successfully induced apoptosis in HT-29 cells by increasing the production of ROS and Ca2+, causing DNA damage, and regulating the expression of apoptotic proteins.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Engineering, Chemical
Qing Su et al.
Summary: A versatile air filtration membrane was developed using poly (aryl sulfide sulfone)/graphene oxide@silver nanoparticles. It demonstrated high filtration efficiency, excellent biocompatibility, and strong antimicrobial properties against bacteria.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Editorial Material
Cell Biology
Pei-Hui Lin et al.
Article
Cell Biology
Haruka Chino et al.
Summary: The endoplasmic reticulum (ER) plays multiple roles in cellular processes. Its quantity and quality are regulated by the ubiquitin-proteasome system and autophagy, specifically ER-phagy. ER-phagy includes two types: macro-ER-phagy and micro-ER-phagy. This review provides an overview of ER-phagy, focusing on its membrane dynamics, molecular mechanisms, substrate specificity, and physiological significance.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Erika Riederer et al.
Summary: Lysosomes have important functions in various cellular processes, and their ion channels and transporters play a crucial role in maintaining lysosomal permeability and function. These channels are regulated by various factors, and genetic variations in their genes are linked to diseases. Recent studies suggest that targeting lysosomal channels may hold promise for therapeutic interventions in human diseases.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Engineering, Environmental
Qiang Yang et al.
Summary: This study developed a strategy of autophagy inhibition-enhanced apoptosis/ferroptosis using DOX-loaded nanosheets. This strategy enhances the therapeutic effect by inhibiting the self-repairing capacity of tumor cells and promoting apoptosis and ferroptosis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Cell Biology
Xinyu Ma et al.
Summary: Biomolecular condensates are membraneless compartments that can undergo phase transitions and are tightly regulated for normal cellular function. Autophagy receptors recognize and target biomolecular condensates, facilitating their degradation through a process called biocondensophagy. Various autophagy receptors have been identified that specifically target biomolecular condensates with different phase transition states, and they also play a role in organizing the phase transition for efficient biocondensophagy. This article discusses the latest discoveries on how autophagy receptors recognize biomolecular condensates.
TRENDS IN CELL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Sara Zaher et al.
Summary: Nanoscale drug carriers have significant potential for improving drug bioavailability, targeting delivery, and release control. Natural polymers, such as proteins, possess favorable properties for use as nanosized drug delivery carriers and substitutes for synthetic polymers. Protein nanocarriers offer advantages including high drug-binding capability and specific tumor targeting. This review discusses the properties of different protein biopolymers and their applications as drug delivery carriers, focusing on their antitumor effects.
ADVANCES IN TRADITIONAL MEDICINE
(2023)
Article
Environmental Sciences
Gregory E. Onaiwu et al.
Summary: This study investigates the relationship between the concentration of PM2.5 and meteorological parameters in Benin City. The results show that PM2.5 concentration varies between the dry and wet seasons, and there is a positive correlation between temperature and solar radiation with PM2.5 concentration, while there is a negative correlation between pressure and PM2.5 concentration.
AEROSOL SCIENCE AND ENGINEERING
(2023)
Review
Environmental Sciences
Laxmi Kant Bhardwaj et al.
Summary: Nanotechnology involves the generation and application of nanoparticles, which have various industrial uses. They can be used for disease diagnosis, targeted drug delivery, and as active components. However, nanoparticles also have toxic effects on ecosystems.
AEROSOL SCIENCE AND ENGINEERING
(2023)
Review
Cell Biology
Barbara Tedesco et al.
Summary: Each protein must be correctly synthesized, folded, and transported to its appropriate location. Failure in these steps can lead to protein misfolding and potential damage. Cells have well-characterized protein quality control systems, including autophagy and chaperone-assisted selective autophagy (CASA), to minimize such issues. The CASA complex, composed of HSPA, HSPB8, and BAG3 proteins, is essential for maintaining protein homeostasis and mutations in these genes can result in (cardio)myopathies and neurodegenerative diseases. This article summarizes the current understanding of the CASA complex and discusses its involvement in diseases and potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Luyao Tian et al.
Summary: Natural products serve as an important database for the development of anti-cancer drugs, but their low water solubility and poor biocompatibility limit their efficacy. This study demonstrates that pentacyclic triterpenoids (PTs) can be prepared into carbon dots (CDs) to improve their properties. The PT-CDs exhibit improved water solubility and biocompatibility, and can specifically target tumor cells and induce cell death more effectively than the raw materials.
BIOORGANIC CHEMISTRY
(2023)
Article
Zoology
Chen Zhao et al.
Summary: This study investigated the protective effect of Nar on Cd-induced toxicity in rats. The results showed that Cd caused pathological changes in the kidneys, increased oxidative stress, and induced autophagy. However, Nar significantly attenuated these effects by reducing oxidative stress and inhibiting autophagy.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hyun-Young Lee et al.
Summary: Arsenic induces cytotoxicity in non-small-cell lung cancer cells through the coordinated action of p62 and Nix signaling, affecting mitochondrial membrane potential and caspase protein cleavage. The modulation of p62 and Nix by MAPK pathways regulates arsenic-induced cytotoxicity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Sergey Zavadskiy et al.
Summary: The concept of oxidative distress arises from the imbalance between oxidants and antioxidants, leading to biomolecular damage. Compromised spatiotemporal control of reactive species generation and removal underlies protein damage and dysfunction of protein degradation machinery, resulting in aging and age-related diseases. The 20S proteasome and autophagy-lysosome pathways play crucial roles in the degradation and elimination of oxidatively damaged proteins. Future investigations in this field may lead to the discovery of new drugs targeting dysregulated cell signaling and protein degradation machinery to combat aging and age-related chronic diseases.
Article
Environmental Sciences
Kristen Yeh et al.
Summary: Thirdhand smoke (THS) refers to the contamination that remains indoors after smoking. This study reviews the composition and behavior of different types of indoor THS, including from tobacco, e-cigarettes, cannabis, and illicit substances. Modeling results suggest that volatile compounds are inhaled, while water-soluble compounds are absorbed by the skin.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Huan Wang et al.
Summary: The experiment aimed to investigate the effects of Cadmium (Cd) on growth performance, blood biochemical parameters, hepatocyte apoptosis and autophagy of weaned piglets. Results showed that Cd significantly decreased body weight and daily feed intake, and increased feed-to-gain ratio. Cd treatment also led to a significant decrease in red blood cells, hemoglobin, hematocrit, total protein, albumin, copper content and iron content. Liver injury was observed in the Cd-exposed group. Cd exposure induced oxidative stress, activated the AMPK/PPAR-gamma/NF-kappa B pathway, and finally induced autophagy and apoptosis.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Emma Lankford et al.
Summary: This study revealed that the proposed ternary Cr(III)-histidine-DNA complexes do not exist, instead weakly bound chromium histidine complexes are formed. Therefore, caution should be taken when interpreting the results of biological studies where ternary adducts of Cr(III), histidine, and DNA were made from prereacted chromium histidinate.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Review
Instruments & Instrumentation
Shloka Negi et al.
Summary: Autophagy is a catabolic process that responds to nutrient or metabolic emergencies. Nanoparticles can induce or block autophagy, playing a crucial role in cancer. Autophagy has paradoxical effects in cancer and its role varies at different stages of the disease.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Andrea Gubas et al.
Summary: Autophagy is a highly conserved cellular process for degrading abnormal cellular components and foreign pathogens, which can be selective or nonselective. Autophagy receptors play a crucial role in linking and degrading cell components during autophagy, undergoing structural modifications to fulfill their function.
Article
Biochemistry & Molecular Biology
Hongrui Guo et al.
Summary: This study investigated the role of autophagy in copper-induced spermatogenesis disorder. Copper can induce autophagy via the AMPK-mTOR pathway and oxidative stress. Inhibition of autophagy increases cell damage and spermatogenesis disorder, while co-treatment with an apoptosis inhibitor can alleviate the disorder. Autophagy may also aggravate copper toxicity by promoting ferroptosis.
Article
Cell Biology
Chimwemwe Mwase et al.
Summary: Aberrant remodeling of the asthmatic airway, potentially caused by mechanical compression, leads to increased expression and secretion of tenascin C (TNC) protein in bronchial epithelial cells. This process depends on ERK and TGF-beta receptor pathways, and can result in the release of extracellular vesicles containing TNC.
Article
Cell Biology
Qiang Wang et al.
Summary: In this study, it was found that Trim33 can control trypsin activation and autophagy through mediating ubiquitination. Trim33 can regulate zymophagy by regulating the expression of VMP1, and its transcriptional regulatory mechanism is associated with the binding of long non-coding RNA TCONS_00021785 and miR-21-5p.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh et al.
Summary: Autophagy plays a dual role in normal cells and tumors, and targeting autophagy using nanoparticles can enhance cancer therapy. Nanocarriers can deliver autophagy regulators and chemotherapeutic agents, while nanomaterials can affect key components of autophagy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Xia Zhao et al.
Summary: The toxicity induced by cadmium exposure in swine is associated with lysosomal dysfunction caused by inhibition of autophagy flux.
Review
Medicine, Research & Experimental
Peter J. Barnes et al.
Summary: Autophagy is a cellular process that removes damaged molecules and organelles, and abnormalities in autophagy may contribute to the pathogenesis of chronic diseases like asthma and COPD. Autophagy can be either increased or decreased depending on the cell type and environment, making it challenging to target therapeutically. Some existing drugs can activate or inhibit autophagy, but more selective drugs are being developed.
Article
Cell Biology
Anne Simonsen et al.
Summary: Autophagy is crucial for maintaining cellular homeostasis by degrading damaged or unnecessary cellular components. Recent research has provided insights into the function of autophagy proteins and their role in disease pathogenesis.
CURRENT OPINION IN CELL BIOLOGY
(2022)
Article
Environmental Sciences
Yatao Du et al.
Summary: This study reveals that PFOA has cytotoxic effects on human placental trophoblast cells, primarily through triggering cellular proliferation and apoptosis via endoplasmic reticulum (ER) stress. PFOA-induced ER stress can activate cellular proliferation and apoptosis through the ROS or UPR signaling pathways. This study highlights the significant impact of PFOA on normal development and function of the placenta.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Zhaojin Zeng et al.
Summary: This study found that ferroptosis plays an important role in house dust mite-induced asthma models, and ferroptosis inhibitors can reduce airway inflammation. This research reveals that ferroptosis may be a potential treatment target for house dust mite-induced asthma.
Review
Biochemistry & Molecular Biology
Michal Rakowski et al.
Summary: This review focuses on the modulation of autophagy by selected vitamins and nutraceuticals, and their potential value in the treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xinjie Guan et al.
Summary: Selective autophagy plays an important role in the pathogenesis of Alzheimer's disease, and regulating selective autophagy can be an effective strategy for controlling this pathological process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mahesh Ramalingam et al.
Summary: In this study, it was found that Rotenone inhibits mitochondrial complex I, leading to neurodegeneration and aggregation of α-syn, resulting in Parkinson's disease. Our previous research has shown that neurogenic differentiated human adipose tissue-derived stem cell-conditioned medium (NI-hADSC-CM) has a protective effect against Rotenone-induced toxicity. This study further discovered that NI-hADSC-CM can modulate autophagy signaling pathways, alleviating α-syn aggregation in Parkinson's disease and other neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Yasaman Esmaeili et al.
Summary: Protein homeostasis is crucial for cell function, and disruption of the molecular mechanisms involved in this process may contribute to neurodegenerative diseases. Autophagy disruption, oxidative stress, and ER stress are the main molecular mechanisms underlying neurodegeneration, and they have synergistic effects on each other. Therefore, targeting the crosstalk between these pathways may play a critical role in healing neurodegenerative diseases.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Cardiac & Cardiovascular Systems
Eddie Tam et al.
Summary: Both iron overload and deficiency can contribute to the development of cardiomyopathy. This review focuses on the regulation of myocardial autophagy by iron and the potential therapeutic effects of targeting the crosstalk between autophagy and other cellular processes implicated in heart failure, such as oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, and ferroptosis.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Environmental Sciences
Xiaofei Zhou et al.
Summary: The article discusses the perturbation of nanoparticles on cell autophagy and emphasizes the importance of nanosafety. It summarizes the recent research progress, discusses the basic process of autophagy and its relationship with human diseases, and reviews the perturbation of different types of nanoparticles on autophagy.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Sujin Park et al.
Summary: Exposure to ambient particulate matter (PM) has adverse health effects, but the molecular mechanism of PM-mediated toxicity is largely unknown. This study reveals that water-soluble inorganics like nitrate and sulfate ions can penetrate the lung surfactant barrier and disrupt gene expression in the lungs. The exposure to nitrate and sulfate ions activates cholesterol biosynthetic metabolism and induces the expression of genes related to tumorigenesis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Chemistry, Multidisciplinary
Peizheng Xiong et al.
Summary: Metal-based nanoparticles play important roles in various fields, but their complex migration and transformation pathways may lead to unpredictable toxic effects on human and ecosystem health. This review summarizes the mechanisms and evaluation methods of cytotoxicity, and analyzes the typical effects on the nervous, immune, reproductive, and genetic systems. Furthermore, the challenges and opportunities for enhancing the safety of metal-based nanoparticles for practical applications are discussed.
Article
Biochemistry & Molecular Biology
Ying Jiang et al.
Summary: This study demonstrates the importance of Cav-1 protein in regulating mitochondrial dynamics and mitophagy, highlighting its potential as a novel target for cancer therapy.
Article
Food Science & Technology
Mengting Shang et al.
Summary: This study evaluated the effects of silver nanoparticles (AgNPs) on different stages of autophagy and found that they induced neuroinflammation and blocked autophagic flux. AgNPs hindered autophagic flux by inhibiting the fusion between autophagosomes and lysosomes, aggravating the neurotoxicity caused by AgNPs.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Md. Ataur Rahman et al.
Summary: This article discusses the pathological features of Alzheimer's disease and the important role of autophagy pathway in prevention and treatment. By regulating autophagy, it is possible to effectively reduce the formation of protein aggregates associated with Alzheimer's disease, making it a potential therapeutic approach.
Article
Chemistry, Physical
Mehran Alavi et al.
Summary: Metal-based nanoparticles can act as effective antiviral agents against various types of viruses. Their antiviral activities can be modulated by different preparation methods and surface modifications. These nanoparticles can be used as aqueous dispersions or incorporated into composite materials. The major antiviral mechanisms include disrupting viral attachment, generating reactive oxygen species, and inactivating viral glycoproteins. The physicochemical properties of the nanoparticles, such as size and surface modification, play a role in their antiviral efficacy.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Kamil Seyrek et al.
Summary: Breast cancer is the most common cancer in women worldwide, and drug resistance and disease recurrence are the main causes of treatment failure. Modulating autophagy in combination with inducing apoptosis may provide a promising strategy for breast cancer treatment.
BIOCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Ravichandran Rakesh et al.
Summary: Autophagy is a significant mechanism related to cellular stress, metabolism, and cancer, but its role in cancer is still not well understood. Autophagy involves modifications of various proteins and pathways and is influenced by the interaction between tumor cells and their microenvironment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Samuel J. Rodgers et al.
Summary: This study reveals an endosome-dependent phosphoinositide pathway that regulates lysosome repopulation during basal autophagy. This pathway involves the sequential actions of PI3K alpha, INPP4B, and PIKfyve, which contribute to autophagic degradation and protection against proteotoxic stress. These findings provide insights into the coordination of lysosome regeneration during autophagy.
Review
Cell Biology
Manpreet Kaur et al.
Summary: Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder that burdens patients and is a leading cause of death worldwide. While cigarette smoke is recognized as the main causative factor, air pollution, particularly particulate matter (PM), has gained attention in recent years due to the increasing prevalence of COPD among non-smokers. Epidemiological studies have shown a strong correlation between airborne PM and COPD incidence and exacerbations. PM-induced oxidative stress is believed to play a major role in COPD inflammation, although the exact molecular mechanisms are still poorly understood. Mitochondrial dysfunction and autophagy have also emerged as important factors in COPD pathogenesis associated with oxidative stress. This review aims to understand the key molecular players in PM-mediated COPD pathogenesis by analyzing various experimental studies and epidemiological data, with the goal of identifying relevant preventive and therapeutic targets.
INFLAMMATION RESEARCH
(2022)
Review
Cell Biology
Eugenia Almacellas et al.
Summary: The functions of autophagy and lysosomes in mitosis are still controversial. On one hand, autophagy seems to be inhibited during mitosis to protect the genetic material. On the other hand, selective autophagy and functional lysosomes are necessary for accurate chromosome segregation.
JOURNAL OF CELL SCIENCE
(2022)
Article
Plant Sciences
Pei-Ching Wu et al.
Summary: The study demonstrates that Alternaria alternata can resist high levels of reactive oxygen species (ROS) and autophagy plays a protective role in oxidative stress. Mutation of the AaAtg8 gene impairs autophagy, leading to the accumulation of peroxisomes and decreased virulence.
MOLECULAR PLANT PATHOLOGY
(2022)
Review
Pharmacology & Pharmacy
Md. Ataur Rahman et al.
Summary: Kidney diseases are a major concern worldwide, and mitochondrial dysfunction plays a role in their pathogenesis. Studies have shown that small-molecule natural products can improve renal function and mitigate the progression of kidney disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Yaser Rehman et al.
Summary: The development of smart, efficient and multifunctional material systems is crucial for addressing current and future health challenges. Nanomaterials with theranostic properties have provided a cost-effective and efficient solution for disease treatment, especially for cancer treatment. The size, shape and surface properties of nanoparticles play a critical role in achieving theranostic function in the microenvironment. In the last decade, various strategies for the synthesis of biocompatible theranostic nanostructures have been introduced. The review of the biological behavior of reported metal-based nanostructures will aid in the conceptualization of novel designs and synthesis strategies for advanced nanotheranostic systems.
Review
Pharmacology & Pharmacy
Xiaoli Tang et al.
Summary: Drug-induced cardiotoxicity not only affects drug development but also contributes to the high morbidity and mortality rates of cardiovascular diseases. Mitochondrial impairment, a common form of cardiotoxicity, has not received enough attention in preclinical cardiac safety tests. This review discusses the characteristics of mitochondria in cardiomyocytes, drug-induced mitochondrial toxicities, and the integration of mitochondrial toxicity and proarrhythmic risk assessments in cardiac safety evaluation.
Review
Biochemistry & Molecular Biology
Ge Yu et al.
Summary: Autophagy is a conserved process in cell survival and cell death, enabling the degradation of cytoplasmic components. It has the primary role of delivering cytoplasmic components to vacuoles or lysosomes for degradation and can also regulate cell death in certain ways, with complex crosstalk between different pathways.
Article
Biochemistry & Molecular Biology
Ali Koskela et al.
Summary: Antioxidant systems play key roles in elderly diseases, including age-related macular degeneration (AMD). This study investigated the protective effects of nature-inspired hybrids on retinal pigment epithelial (RPE) cells. The hybrids increased the expression of Nrf2-target genes and improved intracellular redox balance without affecting autophagy flux. Furthermore, the hybrids enhanced cell survival and reduced inflammation when exposed to proteasome and autophagy inhibitors. The study suggests that Nrf2 is a valuable target for treating AMD.
Article
Neurosciences
Ekramy Elmorsy et al.
Summary: This study found that acute or chronic exposure to pesticides can lead to neurotoxicity, with different effects in different regions of the brain. The hippocampus and corpus striatum are more susceptible to pesticide effects, showing disrupted cellular bioenergetics, increased oxidative stress, and inhibition of enzymes associated with neurodegeneration.
Review
Biochemistry & Molecular Biology
Veronica Angela Maria Vitto et al.
Summary: Autophagy is a tightly regulated process that maintains cellular homeostasis by degrading unnecessary or dysfunctional components and recycling metabolic substrates. It plays a dual role in cancer, promoting tumor progression in advanced stages while inhibiting tumor development in early stages. Autophagy also affects the response to anticancer therapy.
Review
Biochemistry & Molecular Biology
Marianna Carinci et al.
Summary: Autophagy is a crucial process for maintaining cell homeostasis and cell survival. Dysregulation of autophagy is implicated in various lung diseases and infections. It can have both protective and harmful effects in lung infections and diseases.
Review
Andrology
Damilare E. Rotimi et al.
Summary: Apoptosis and autophagy play important roles in regulating testicular function, and their cross-talk can affect the survival and death of testicular cells.
Article
Environmental Sciences
Yao Liu et al.
Summary: By studying cell and animal models exposed to PM2.5, a potential relationship between IL24 and autophagy was discovered, and the role of IL24 in PM2.5-induced lung injury was validated. This finding may provide new clues for the research of biomarkers and therapeutic targets in lung diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Ophthalmology
Karina Luiza Dias-Teixeira et al.
Summary: The cornea and tear film play a crucial role in maintaining transparency and refraction of light in the eye. The avascular cornea serves as a model for studying the role of autophagy in homeostasis regulation. Mutations and inflammation can disrupt autophagic flux and lead to dystrophies or worsen inflammation. Novel topical therapies can be developed based on this model to restore homeostasis.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Cell Biology
Lilian Correa Costa-Beber et al.
Summary: This article reviews evidence supporting that chronic exposure to PM2.5 depletes HSR and determines the ability to solve the initial stress.
INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Nada Orsolic et al.
Summary: Interest in natural products as alternative sources of pharmaceuticals for chronic diseases, including tumors, has been renewed in recent years. Propolis and its compounds have been found to modulate various processes involved in cancer progression, such as cell proliferation, apoptosis, and oncogene signaling pathways. They also exhibit antimetastatic, anti-angiogenic, anti-inflammatory, and antiviral/bactericidal activities, as well as modulation of gut microbiota and attenuation of chemotherapy side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jianwei Zhang et al.
Journal of Environmental Sciences-China
(2022)
Article
Multidisciplinary Sciences
Damian E. Berardi et al.
Summary: Hepatic steatosis is a major factor in the development of hepatocellular carcinoma (HCC). In this study, BNIP3, a mitochondrial cargo receptor, was identified as a suppressor of HCC that reduces lipid accumulation and inhibits tumor cell growth. Deletion of Bnip3 in a mouse model of HCC resulted in shorter tumor latency and increased tumor burden, accompanied by early lipid accumulation. Low BNIP3 expression in human HCC was also associated with increased lipid content and worse prognosis.
Article
Marine & Freshwater Biology
Dong-Lei Wu et al.
Summary: This study systematically assessed the toxic effects of different concentrations of PFOA on zebrafish liver cells. It was found that PFOA inhibited cell viability and caused massive accumulation of autophagic vacuoles. Transcriptome analysis revealed significant changes in the expression of genes involved in autophagy, signal transduction, immune system, and other pathways. These findings provide a scientific basis for understanding the toxic effects and potential mechanisms of PFOA on zebrafish.
AQUATIC TOXICOLOGY
(2022)
Review
Clinical Neurology
Antonio Ventriglio et al.
Summary: Pollutant agents are increasingly impacting public health, with a growing focus on their association with mental health disorders such as anxiety, mood, and psychotic syndromes. The pathogenesis involves direct and indirect effects of environmental pollutants on the brain, either through biological impacts on the Central Nervous System or from stress generated over time. However, most emerging evidence remains inconclusive on the exact relationship between pollution and mental health problems.
Article
Biochemistry & Molecular Biology
Md. Ataur Rahman et al.
Summary: Oxyresveratrol affects the function of astrocytes by promoting autophagy signaling and inhibiting APP production. Co-treatment with chloroquine significantly enhances autophagic flux, and the regulation of autophagy substrates and pathways by Oxyresveratrol depends on the PI3 kinase pathway.
Article
Multidisciplinary Sciences
Yan-Hong Cui et al.
Summary: Chronic low-level exposure to arsenic inhibits autophagic degradation of FTO, leading to FTO stabilization and reduced m6A RNA methylation in keratinocytes and subsequent malignant transformation.
NATURE COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Mahdi Balali-Mood et al.
Summary: Industrial activities of the last century have led to increased human exposure to heavy metals such as mercury, lead, chromium, cadmium, and arsenic, resulting in acute or chronic poisonings through water, air, and food. These heavy metals accumulate in the body, causing toxic effects on various tissues and organs by disrupting cellular events and inducing oxidative stress. Common mechanisms of action of these metals include ROS generation, inhibition of antioxidant defense, enzyme inactivation, and selective binding to specific macromolecules, some leading to genomic instability and carcinogenicity through DNA damage and oxidative stress. Despite current knowledge, heavy metal poisoning incidents remain prevalent, necessitating preventive measures and effective treatment, possibly including chelation therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ming Zhang et al.
Summary: In COPD patients, airway epithelial cells show increased phosphorylation of MAPK15 and ULK1, as well as enhanced expression of Beclin1 and the ratio of LC3II to LC3I. Cigarette smoke extract activates the MAPK15-ULK1 signaling pathway, leading to mitophagy and mitochondrial oxidative stress in airway epithelial cells. Targeting this pathway may be a potential therapeutic strategy for COPD.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Medicine, Research & Experimental
Wen Li et al.
Summary: Autophagy is a physiological process that degrades over-abundant or damaged organelles via the lysosomal system, induced by stress and occurring in both non-selective and selective manners. Selective autophagy plays a crucial role in maintaining cellular homeostasis and its dysfunction is implicated in various diseases.
Review
Environmental Sciences
Bingnan He et al.
Review
Pharmacology & Pharmacy
Md. Ataur Rahman et al.
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Environmental Sciences
Md Ataur Rahman et al.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Md. Sahab Uddin et al.
Review
Biochemistry & Molecular Biology
Jayant Patwa et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Cell Biology
Kalina Duszka et al.
Review
Biochemistry & Molecular Biology
Pablo Scharf et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Chemistry, Medicinal
Md Sahab Uddin et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2020)
Review
Pharmacology & Pharmacy
Emmanuel Naveen Raj et al.
ADVANCED THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Peng Zhang et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2020)
Review
Cell Biology
Mojgan Djavaheri-Mergny et al.
Article
Toxicology
Lingmin Zhang et al.
TOXICOLOGY LETTERS
(2019)
Review
Toxicology
Maija Pesonen et al.
TOXICOLOGY LETTERS
(2019)
Article
Biochemistry & Molecular Biology
Nicolas Mercado et al.
Article
Cell Biology
Neeraj Vij et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2018)
Review
Biotechnology & Applied Microbiology
Barry Boland et al.
NATURE REVIEWS DRUG DISCOVERY
(2018)
Article
Agriculture, Multidisciplinary
Rui Chen et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Cell Biology
Tania Colasanti et al.
CELL DEATH & DISEASE
(2018)
Article
Cell Biology
Yunxiao Li et al.
Article
Toxicology
Lilian Cristina Pereira et al.
TOXICOLOGY IN VITRO
(2017)
Article
Cell Biology
Ramu Venkatesan et al.
CELL DEATH DISCOVERY
(2017)
Review
Biochemistry & Molecular Biology
Md. Ataur Rahman et al.
Article
Biochemistry & Molecular Biology
Md. Ataur Rahman et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2017)
Article
Pharmacology & Pharmacy
Md. Ataur Rahman et al.
BIOCHEMICAL PHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Ian Tran et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2015)
Review
Chemistry, Medicinal
Sarmishtha Chatterjee et al.
CHEMICAL RESEARCH IN TOXICOLOGY
(2014)
Review
Biochemistry & Molecular Biology
Ruben K. Dagda et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2013)
Article
Neurosciences
Elzbieta Janda et al.
MOLECULAR NEUROBIOLOGY
(2012)
Article
Multidisciplinary Sciences
Jonathan Wills et al.
Article
Biochemistry & Molecular Biology
S. H. Wang et al.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2008)
Article
Environmental Sciences
Mario Di Gioacchino et al.
SCIENCE OF THE TOTAL ENVIRONMENT
(2008)
