期刊
JOURNAL OF SEPARATION SCIENCE
卷 39, 期 10, 页码 1919-1925出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201600112
关键词
Dendritic polyethyleneimine; Glycoproteins; Magnetic separation; Surface imprinting
资金
- National Natural Science Foundation of China [21305107, 21305086]
- Fundamental Research Funds for the Central Universities [xjj2013041, 08142034]
- China Postdoctoral Science Foundation [2014M562388]
- Research Innovation Program of Shanghai Municipal Education Commission [14YZ138]
Glycoproteins are crucial inmassive physiological events and clinical application. It is necessary to prepare new materials to isolate the specific glycoprotein. New and simple core-shell molecularly imprinted polymers were prepared by surface imprinting. The polymers are synthesized with magnetic nanoparticles as the core, water-soluble dendritic polyethyleneimine as the monomer and the ovalbumin as the template. The prepared imprinted polymers showed thin imprinted shell, biocompatibility and superparamagnetic properties. The resultant materials exhibited fast kinetics, high adsorption capacity, perfect selectivity and reusability. More important, they can absorb the template glycoprotein from the neutral solution and successfully be applied to recognize the ovalbumin from egg white, which means that they can provide an alternate method to isolate glycoprotein from bodily fluids.
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