期刊
JOURNAL OF SEPARATION SCIENCE
卷 39, 期 10, 页码 1863-1872出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201600055
关键词
Ionic liquid; Molecular imprinting; L-Phenylalanine; Pickering emulsion; Solid-phase extraction
资金
- National Nature Science Foundation of China [21174111, 51433008]
A novel L-phenylalanine molecularly imprinted solid-phase extraction sorbent was synthesized by the combination of Pickering emulsion polymerization and ion-pair dummy template imprinting. Compared to other polymerization methods, the molecularly imprinted polymers thus prepared exhibit a high specific surface, large pore diameter, and appropriate particle size. The key parameters for solid-phase extraction were optimized, and the result indicated that the molecularly imprinted polymer thus prepared exhibits a good recovery of 98.9% for L-phenylalanine. Under the optimized conditions of the procedure, an analytical method for L-phenylalanine was well established. By comparing the performance of the molecularly imprinted polymer and a commercial reverse-phase silica gel, the obtained molecularly imprinted polymer as an solid-phase extraction sorbent is more suitable, exhibiting high precision (relative standard deviation 3.2%, n = 4) and a low limit of detection (60.0 +/- 1.9 nmol.L-1) for the isolation of L-phenylalanine. Based on these results, the combination of the Pickering emulsion polymerization and ion-pair dummy template imprinting is effective for preparing selective solid-phase extraction sorbents for the separation of amino acids and organic acids from complex biological samples.
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