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Article
Medicine, General & Internal
Safety and immunogenicity of a bivalent SARS-CoV-2 protein booster vaccine, SCTV01C, in adults previously vaccinated with mRNA vaccine: a randomized, double-blind, placebo-controlled phase 1/2 clinical trial
Suad Hannawi et al.
Summary: This study aimed to evaluate the safety and immunogenicity of SCTV01C, a novel bivalent protein vaccine, as a booster for individuals who previously received two doses of mRNA vaccine. The results showed that SCTV01C vaccine had high cross-neutralizing antibody responses against Delta and Omicron variants, and was well-tolerated.
EBIOMEDICINE (2023)
Review
Urology & Nephrology
Vaccination in patients with kidney failure: lessons from COVID-19
Nina Babel et al.
Summary: Infection is a major cause of death in patients with chronic kidney disease (CKD). However, vaccination efficacy is reduced in CKD patients due to immune alterations caused by kidney dysfunction and chronic inflammation. COVID-19 has detrimental effects in CKD patients, making successful vaccination against it crucial. While some CKD patients may not generate humoral immunity after vaccination, their vaccine-specific T cell response may still provide protection against severe COVID-19. Establishing protection correlates for CKD patients is urgently needed for personalized vaccination strategies.
NATURE REVIEWS NEPHROLOGY (2022)
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