Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche

Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Article Reproductive Biology

Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation

Lan Dai et al.

Summary: This study highlights the critical role of SphK1 in adipocyte-induced EOC cell proliferation, involving ERK phosphorylation and the S1PR1 and S1PR3 signaling pathways. The findings suggest a new potential target for EOC therapy.

JOURNAL OF OVARIAN RESEARCH (2021)

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Review Cell Biology

Sphingolipids in metabolic disease: The good, the bad, and the unknown

Christopher D. Green et al.

Summary: The dysregulation of sphingolipid metabolism is associated with the pathogenesis of metabolic diseases, with ceramide exacerbating metabolic diseases by regulating signaling and metabolic pathways, while its metabolite S1P and its receptors have multifaceted and sometimes opposing actions in tissues.

CELL METABOLISM (2021)

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Review Cell Biology