期刊
CELL RESEARCH
卷 26, 期 2, 页码 229-238出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cr.2015.148
关键词
transgenerational inheritance; longevity; C. elegans; steroid signaling
类别
资金
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- Helen Hay Whitney post-doctoral fellowship
- National Institute on Aging of the National Institute of Health (NIH) [AG043550]
- Max Planck Gesselschaft
- NIH [GM058012]
- Ellison Foundation Senior Scholar Award
- Mitani S
- National Bioresource Project for the Experimental Animal 'Nematode C. elegans'
- Moerman D laboratories for C. elegans strains
Complex organismal properties such as longevity can be transmitted across generations by non-genetic factors. Here we demonstrate that deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase, spr-5, causes a trans-generational increase in lifespan. We identify a chromatin-modifying network, which regulates this lifespan extension. We further show that this trans-generational lifespan extension is dependent on a hormonal signaling pathway involving the steroid dafachronic acid, an activator of the nuclear receptor DAF-12. These findings suggest that loss of the demethylase SPR-5 causes H3K4me2 mis-regulation and activation of a known lifespan-regulating signaling pathway, leading to trans-generational lifespan extension.
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