4.3 Review

Mometasone/Indacaterol/Glycopyrronium (MF/IND/GLY) and MF/IND at Different MF Strengths versus Fluticasone Propionate/Salmeterol Xinafoate (FLU/SAL) and FLU/SAL+ Tiotropium in Patients with Asthma

相关参考文献

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Review Cardiac & Cardiovascular Systems

A systematic literature review of burden of illness in adults with uncontrolled moderate/severe asthma

Alexandrosz Czira et al.

Summary: This article provides a systematic review of the burden of moderate/severe uncontrolled asthma, including prevalence, clinical measures, health-related quality of life, and economic burden. It reveals that patients with uncontrolled asthma have poor lung function, substantial exacerbation burden, and impaired quality of life. The direct, indirect, and total costs associated with managing uncontrolled asthma are also significant.

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Indacaterol/glycopyrronium/mometasone fixed dose combination for uncontrolled asthma

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Summary: The combination of LABA/LAMA/ICS in a fixed dose approved in Europe, IND/GLY/MF has shown superiority over traditional LABA/ICS combinations in improving lung function for uncontrolled asthma. Additionally, the use of a digital companion with IND/GLY/MF therapy has shown benefits in improving treatment adherence, reducing rescue inhaler usage, and increasing patient satisfaction and asthma control.

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Medication adherence in patients with asthma using once-daily versus twice-daily ICS/LABAs

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Summary: This study compared medication adherence and persistence among asthma patients receiving different ICS/LABA treatments. Results showed higher medication adherence with FF/VI compared to B/F or FP/SAL. Patients using FF/VI also had longer persistence with the index medication.

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Kenneth Chapman et al.

Summary: In patients with inadequately controlled asthma, high-dose MF/IND showed significant reductions in asthma exacerbations and improvement in lung function compared to high-dose FLU/SAL. Similarly, medium-dose MF/IND and high-dose FLU/SAL also improved outcomes, but at a lower ICS dose.

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Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial

Laurie A. Lee et al.

Summary: In patients with uncontrolled moderate or severe asthma using ICS/LABA, adding UMEC improved lung function but did not significantly reduce moderate and/or severe exacerbations. Single-inhaler FF/UMEC/VI is an effective treatment option with a favorable risk-benefit profile. Higher dose FF primarily reduced exacerbations, especially in patients with elevated biomarkers of type 2 airway inflammation. Further studies are needed to confirm the effects of type 2 inflammatory biomarkers on treatment outcomes in asthma.

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Pharmacokinetics of indacaterol, glycopyrronium and mometasone furoate administered as an inhaled fixed-dose combination in Japanese and Caucasian healthy subjects

Satoru Inoue et al.

Summary: The pharmacokinetics of IND, GLY, and MF when delivered as a fixed-dose combination were similar between Japanese and Caucasian male subjects. The IND/GLY/MF combination was safe and well tolerated in both ethnic groups.

BMC PULMONARY MEDICINE (2021)

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Uncontrolled asthma: a retrospective cohort study in Japanese patients newly prescribed with medium-/high-dose ICS/LABA

Hiromasa Inoue et al.

Summary: Despite guideline-based therapies, a significant proportion of asthma patients in Japan prescribed with inhaled corticosteroid/long-acting beta(2)-agonist (ICS/LABA) remain uncontrolled, with predictors such as systemic corticosteroid use, exacerbation history, comorbidities, and female gender. Healthcare resource utilization was higher in patients with uncontrolled asthma in both medium-dose and high-dose ICS/LABA cohorts, indicating a need for novel therapies in these patients with persistent asthma.

NPJ PRIMARY CARE RESPIRATORY MEDICINE (2021)

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Salmeterol/Fluticasone Propionate A Review of its Use in Asthma

Kate McKeage et al.

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Mometasone furoate: an inhaled glucocorticoid for the management of asthma in adults and children

Robert L. Cowie et al.

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Indacaterol, a novel inhaled β2-agonist, provides sustained 24-h bronchodilation in asthma

K. M. Beeh et al.

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Improved asthma control with budesonide/formoterol in a single inhaler, compared with budesonide alone

O Zetterström et al.

EUROPEAN RESPIRATORY JOURNAL (2001)