4.6 Article

Linoleate-Enrichment of Mitochondrial Cardiolipin Molecular Species Is Developmentally Regulated and a Determinant of Metabolic Phenotype

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

Long-chain fatty acid oxidation and respiratory complex I deficiencies distinguish Barth Syndrome from idiopathic pediatric cardiomyopathy

Kathryn C. Chatfield et al.

Summary: Barth syndrome (BTHS) is caused by mutations in the TAFAZZIN gene, leading to cardiomyopathy and mitochondrial metabolic abnormalities. Metabolic analysis of myocardial tissue from BTHS patients revealed specific alterations, including deficiencies in cardiolipin content and accumulation of hydrolyzed cardiolipin species, as well as selective depletion of complex I. This suggests a block in mitochondrial fatty acid oxidation and compensatory mechanisms in BTHS cardiomyopathy.

JOURNAL OF INHERITED METABOLIC DISEASE (2022)

Article Food Science & Technology

Linoleic Acid-Rich Oil Alters Circulating Cardiolipin Species and Fatty Acid Composition in Adults: A Randomized Controlled Trial

Rachel M. Cole et al.

Summary: This study found that fortification with LA-rich oil can increase LA(4)CL in adults, while oil with high oleate (OA) safflower had no effect on LA(4)CL. Considering that increasing LA(4)CL can reduce the risk of cardiometabolic diseases, further research is needed to determine if dietary fortification can repair mitochondrial dysfunction.

MOLECULAR NUTRITION & FOOD RESEARCH (2022)

Article Multidisciplinary Sciences

Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle

Alexandre Prola et al.

Summary: Mice deficient for a muscle-specific enzyme of very-long-chain fatty acid synthesis displayed increased basal energy expenditure and protection against high-fat diet-induced obesity. Muscle-specific modulation of the very-long-chain fatty acid pathway was associated with a reduced content of inner mitochondrial membrane phospholipid cardiolipin and a blunted coupling efficiency between the respiratory chain and ATP synthase, which was restored by cardiolipin enrichment. Selective increase of lipid oxidative capacities in skeletal muscle, through the cardiolipin-dependent lowering of mitochondrial ATP production, provides an effective option against obesity at the whole-body level.

SCIENCE ADVANCES (2021)

Article Cardiac & Cardiovascular Systems

Cardiac Energy Metabolism in Heart Failure

Gary D. Lopaschuk et al.

Summary: Changes in cardiac energy metabolism are complex and depend on the severity and type of heart failure, as well as the presence of common comorbidities such as obesity and type 2 diabetes. The failing heart experiences an energy deficit due to decreased mitochondrial oxidative capacity, compensated for by increased ATP production from glycolysis. Alterations in mitochondrial ATP production fuels and fatty acid oxidation contribute to the inefficiency of the failing heart, with potential therapeutic targets in energy metabolic pathways to improve cardiac function.

CIRCULATION RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity

Ying H. Lin et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Article Biochemistry & Molecular Biology

Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria

Catherine H. Le et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Cell Biology

Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity

Mauro Corrado et al.

CELL METABOLISM (2020)

Article Cardiac & Cardiovascular Systems

A Novel Method of Isolating Myofibrils From Primary Cardiomyocyte Culture Suitable for Myofibril Mechanical Study

Kathleen C. Woulfe et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart A Multisystems Approach

Ling Lai et al.

CIRCULATION-HEART FAILURE (2014)

Article Cardiac & Cardiovascular Systems

Dysregulation of cardiolipin biosynthesis in pediatric heart failure

Kathryn C. Chatfield et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)

Article Physiology

Energy Metabolism in the Liver

Liangyou Rui

COMPREHENSIVE PHYSIOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart

Christopher M. Mulligan et al.

CARDIOVASCULAR RESEARCH (2012)

Review Biochemistry & Molecular Biology

The complexity of cardiolipin in health and disease

Steven M. Claypool et al.

TRENDS IN BIOCHEMICAL SCIENCES (2012)

Article Cardiac & Cardiovascular Systems

Bioenergetics, mitochondria, and cardiac myocyte differentiation

George A. Porter et al.

PROGRESS IN PEDIATRIC CARDIOLOGY (2011)

Article Biochemistry & Molecular Biology

Evidence for Physical Association of Mitochondrial Fatty Acid Oxidation and Oxidative Phosphorylation Complexes

Yudong Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure

Genevieve C. Sparagna et al.

JOURNAL OF LIPID RESEARCH (2007)

Review Medicine, General & Internal

Mechanisms of disease - The failing heart - An engine out of fuel

Stefan Neubauer

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Review Cell Biology

Role of cardiolipin alterations in mitochondrial dysfunction and disease

Adam J. Chicco et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)

Article Cardiac & Cardiovascular Systems

A β1-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction

Carmen C. Sucharov et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Molecular symmetry in mitochondrial cardiolipins

M Schlame et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2005)

Article Endocrinology & Metabolism

Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm

A Chabowski et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)