The obesity paradox in patients with atrial fibrillation: Insights from the Gulf SAFE registry

BackgroundThe prognostic impact of obesity on patients with atrial fibrillation (AF) remains under-evaluated and controversial. MethodsPatients with AF from the Gulf Survey of Atrial Fibrillation Events (Gulf SAFE) registry were included, who were recruited from six countries in the Middle East Gulf region and followed for 12 months. A multivariable model was established to investigate the association of obesity with clinical outcomes, including stroke or systemic embolism (SE), bleeding, admission for heart failure (HF) or AF, all-cause mortality, and a composite outcome. Restricted cubic splines were depicted to illustrate the relationship between body mass index (BMI) and outcomes. Sensitivity analysis was also conducted. ResultsA total of 1,804 patients with AF and recorded BMI entered the final analysis (mean age 56.2 +/- 16.1 years, 47.0% female); 559 (31.0%) were obese (BMI over 30 kg/m(2)). In multivariable analysis, obesity was associated with reduced risks of stroke/systematic embolism [adjusted odds ratio (aOR) 0.40, 95% confidence interval (CI), 0.18-0.89], bleeding [aOR 0.44, 95%CI, 0.26-0.74], HF admission (aOR 0.61, 95%CI, 0.41-0.90) and the composite outcome (aOR 0.65, 95%CI, 0.50-0.84). As a continuous variable, higher BMI was associated with lower risks for stroke/SE, bleeding, HF admission, all-cause mortality, and the composite outcome as demonstrated by the accumulated incidence of events and restricted cubic splines. This protective effect of obesity was more prominent in some subgroups of patients. ConclusionAmong patients with AF, obesity and higher BMI were associated with a more favorable prognosis in the Gulf SAFE registry. The underlying mechanisms for this obesity paradox merit further exploration.

Automated summary

This study found that obesity and higher BMI were associated with a more favorable prognosis in patients with atrial fibrillation (AF) in the Gulf SAFE registry. Obesity was associated with reduced risks of stroke/systemic embolism, bleeding, heart failure admission, and a composite outcome. The protective effect of obesity was more prominent in certain subgroups of patients.