期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2022.1097229
关键词
stroke; SARS-CoV-2; COVID-19; coagulation; thrombosis; platelet activation; endothelium activation
This study compared the clinical/radiological characteristics, endothelial and coagulation dysfunction between AIS patients with and without COVID-19, and investigated the role of the SARS-CoV-2 spike protein (SP) in triggering platelet activation. The results showed that COVID-19 patients had higher levels of Factor VIII and von Willebrand factor antigen, which were positively correlated with infarct volume. COVID-19 infection was found to be an independent predictor of infarct volume. SP was detected in the serum of some COVID-19 patients.
Background and purposeAcute ischemic stroke (AIS) is a fearful complication of Coronavirus Disease-2019 (COVID-19). Aims of this study were to compare clinical/radiological characteristics, endothelial and coagulation dysfunction between acute ischemic stroke (AIS) patients with and without COVID-19 and to investigate if and how the SARS-CoV-2 spike protein (SP) was implicated in triggering platelet activation. MethodsWe enrolled AIS patients with COVID-19 within 12 h from onset and compared them with an age- and sex-matched cohort of AIS controls without COVID-19. Neuroimaging studies were performed within 24 h. Blood samples were collected in a subset of 10 patients. ResultsOf 39 AIS patients, 22 had COVID-19 and 17 did not. Admission levels of Factor VIII and von Willebrand factor antigen were significantly higher in COVID-19 patients and positively correlated with the infarct volume. In multivariate linear regression analyses, COVID-19 was an independent predictor of infarct volume (B 20.318, Beta 0.576, 95%CI 6.077-34.559; p = 0.011). SP was found in serum of 2 of the 10 examined COVID-19 patients. Platelets from healthy donors showed a similar degree of procoagulant activation induced by COVID-19 and non-COVID-19 patients' sera. The anti-SP and anti-Fc gamma RIIA blocking antibodies had no effect in modulating platelet activity in both groups. ConclusionsSARS-CoV-2 infection seems to play a major role in endothelium activation and infarct volume extension during AIS.
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