4.6 Article

Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity

Carla Umansky et al.

Summary: Formaldehyde (FA) not only exerts cytotoxicity through DNA damage, but also triggers cellular redox imbalance by reacting with glutathione (GSH). GSH synthesis and the enzyme alcohol dehydrogenase 5 (ADH5) play crucial roles in preventing FA cytotoxicity. These findings are important for patients with mutations in FA detoxification systems and suggest potential therapeutic benefits of thiol-rich antioxidants.

NATURE COMMUNICATIONS (2022)

Article Chemistry, Multidisciplinary

Formaldehyde regulates tetrahydrofolate stability and thymidylate synthase catalysis

Xiaolei Chen et al.

Summary: The study confirms the production of formaldehyde from the degradation of tetrahydrofolic acid, and reveals that their reaction regulates the stability of tetrahydrofolic acid. This discovery identifies a new non-enzymatic feedback mechanism that regulates formaldehyde and folate metabolism, with significant implications for folate-targeting chemotherapy in cancer and other diseases.

CHEMICAL COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Amino acid dependent formaldehyde metabolism in mammals

Matthias Pietzke et al.

COMMUNICATIONS CHEMISTRY (2020)

Article Multidisciplinary Sciences

Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates

Joel D. W. Toh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde

Raphael Reinbold et al.

SCIENTIFIC REPORTS (2020)

Article Multidisciplinary Sciences

Formaldehyde quantification using ampicillin is not selective

Raphael Reinbold et al.

SCIENTIFIC REPORTS (2019)

Article Chemistry, Multidisciplinary

How formaldehyde reacts with amino acids

Jos J. A. G. Kamps et al.

COMMUNICATIONS CHEMISTRY (2019)

Article Multidisciplinary Sciences

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

Guillermo Burgos-Barragan et al.

NATURE (2017)

Article Multidisciplinary Sciences

Comprehensive analysis of human protein N-termini enables assessment of various protein forms

Jeonghun Yeom et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

The mechanism of a formaldehyde-sensing transcriptional regulator

Katie J. Denby et al.

SCIENTIFIC REPORTS (2016)

Review Cell Biology

Histone exchange, chromatin structure and the regulation of transcription

Swaminathan Venkatesh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Article Chemistry, Applied

Investigation on formaldehyde release from preservatives in cosmetics

C. Lv et al.

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (2015)

Article Biochemistry & Molecular Biology

Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate

Zigmund Luka et al.

PROTEIN SCIENCE (2014)

Review Cell Biology

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions

Daniel J. Gibbs et al.

TRENDS IN CELL BIOLOGY (2014)

Review Biotechnology & Applied Microbiology

Reproductive and developmental toxicity of formaldehyde: A systematic review

Anh Duong et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2011)

Article Multidisciplinary Sciences

Identification of Lysine 37 of Histone H2B as a Novel Site of Methylation

Kathryn E. Gardner et al.

PLOS ONE (2011)

Review Nutrition & Dietetics

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

Anne S. Tibbetts et al.

ANNUAL REVIEW OF NUTRITION, VOL 30 (2010)

Article Chemistry, Organic

Studies on the reaction of glutathione and formaldehyde using NMR

Richard J. Hopkinson et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2010)

Article Biochemical Research Methods

Identification of formaldehyde-induced modifications in proteins: Reactions with insulin

Bernard Metz et al.

BIOCONJUGATE CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Regulation of LSD1 histone demethylase activity by its associated factors

YJ Shi et al.

MOLECULAR CELL (2005)

Review Cell Biology

The effects of stress and aging on glutathione metabolism

P Maher

AGEING RESEARCH REVIEWS (2005)

Article Biotechnology & Applied Microbiology

Characterization of formaldehyde-inactivated poliovirus preparations made from live-attenuated strains

J Martín et al.

JOURNAL OF GENERAL VIROLOGY (2003)

Review Medicine, Research & Experimental

The importance of glutathione in human disease

DM Townsend et al.

BIOMEDICINE & PHARMACOTHERAPY (2003)

Article Multidisciplinary Sciences

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

SC Trewick et al.

NATURE (2002)

Article Biochemistry & Molecular Biology

Role of the N-terminal proline residue in the catalytic activities of the Escherichia coli Fpg protein

OM Sidorkina et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)