期刊
PHARMACEUTICALS
卷 15, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ph15121517
关键词
Zingiberaceae; labdane diterpenes; norlabdane diterpenes; bis-labdanic diterpenes; cytotoxicity
This review discusses the distribution, extraction, isolation, and characterization methods of labdane-type diterpenes in the Zingiberaceae plants. It also explores the cytotoxic activities of these compounds against various cancer cell lines and the influence of their structural features.
Over the years, labdane diterpenes, norlabdane diterpenes, and bis-labdanic diterpenes with cytotoxic activities have been identified across various families in the plant kingdom including the Zingiberaceae. The present review discusses the distribution of these labdane-type diterpenes within the Zingiberaceae; their extraction, isolation, and characterization from the respective Zingiberaceae species; the structural similarities and differences within each group and between the different groups of the labdane-type diterpenes; and their cytotoxic activities against breast, cervical, liver, colorectal, pancreatic, lung and prostate cancer cell lines. The review will also provide insight into how the cytotoxic activities of the labdane-type diterpenes are influenced by their structural features.
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