相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease
Dan Liu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Nrf2/Keap1/ARE signaling: Towards specific regulation
Alexey Ulasov et al.
LIFE SCIENCES (2022)
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE)
Rosalba Leuci et al.
MOLECULES (2022)
The multimodal action of genistein in Alzheimer's and other age-related diseases
Cristina Mas-Bargues et al.
FREE RADICAL BIOLOGY AND MEDICINE (2022)
Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer's disease
Gaofeng Zhu et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)
Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis
Anna Sampietro et al.
PHARMACEUTICALS (2022)
Design, Synthesis, and Pharmacological Evaluation of N-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer?s Disease
Bhupinder Kumar et al.
ACS CHEMICAL NEUROSCIENCE (2022)
A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator
Jie Guo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Drug reposition-based design, synthesis, and biological evaluation of dual inhibitors of acetylcholinesterase and ,B-Secretase for treatment of Alzheimer?s disease
Sushant K. Shrivastava et al.
JOURNAL OF MOLECULAR STRUCTURE (2022)
Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer's Disease
Alessia Carocci et al.
ANTIOXIDANTS (2022)
2022 Alzheimer's disease facts and figures
Joseph Gaugler et al.
ALZHEIMERS & DEMENTIA (2022)
Structural Modification, In Vitro, In Vivo, Ex Vivo, and In Silico Exploration of Pyrimidine and Pyrrolidine Cores for Targeting Enzymes Associated with Neuroinflammation and Cholinergic Deficit in Alzheimer's Disease
Muhammad Aamir Javed et al.
ACS CHEMICAL NEUROSCIENCE (2021)
Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations
Rani Sasidharan et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)
Emerging targets in drug discovery against neurodegenerative diseases: Control of synapsis disfunction by the RhoA/ROCK pathway
Olmo Martin-Camara et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors
Anusree Venkidath et al.
MOLECULES (2021)
Microglia in Alzheimer's Disease: A Target for Therapeutic Intervention
Guimei Zhang et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2021)
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease
Michele Rossi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Halogenated Coumarin-Chalcones as Multifunctional Monoamine Oxidase-B and Butyrylcholinesterase Inhibitors
Nisha Abdul Rehuman et al.
ACS OMEGA (2021)
GSK-3β, FYN, and DYRK1A: Master Regulators in Neurodegenerative Pathways
Stefania Demuro et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii
Jong Min Oh et al.
SCIENTIFIC REPORTS (2021)
A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease
Niels D. Prins et al.
ALZHEIMERS RESEARCH & THERAPY (2021)
Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research
Dean G. Brown et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease
Nour M. Moussa-Pacha et al.
MEDICINAL RESEARCH REVIEWS (2020)
Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation
Chaoquan Tian et al.
BIOORGANIC CHEMISTRY (2020)
New Insights Into the Pathogenesis of Alzheimer's Disease
Liyuan Fan et al.
FRONTIERS IN NEUROLOGY (2020)
Role of dietary fatty acids in microglial polarization in Alzheimer's disease
Smita Eknath Desale et al.
JOURNAL OF NEUROINFLAMMATION (2020)
A Perspective on Multi-target Drugs for Alzheimer's Disease
Ondrej Benek et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2020)
Design of enamides as new selective monoamine oxidase-B inhibitors
Fathima Sahla Kavully et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2020)
Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation
Surabhi Shukla et al.
FRONTIERS IN PHARMACOLOGY (2020)
Multitarget Approach to Drug Candidates against Alzheimer's Disease Related to AChE, SERT, BACE1 and GSK3β Protein Targets
Larisa Ivanova et al.
MOLECULES (2020)
A New Potent and Selective Monoamine Oxidase-B Inhibitor with Extended Conjugation in a Chalcone Framework: 1-[4-(Morpholin-4-yl)phenyl]-5-phenylpenta-2,4-dien-1-one
Naseer Maliyakkal et al.
CHEMMEDCHEM (2020)
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease
Julio Rodriguez-Lavado et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain
James Michael Brimson et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2020)
Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities
Daniel A. Rodrigues et al.
MEDICINAL RESEARCH REVIEWS (2020)
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Tiantian Guo et al.
MOLECULAR NEURODEGENERATION (2020)
Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease
Christian Grinan-Ferre et al.
NEUROTHERAPEUTICS (2020)
Functions of p38 MAP Kinases in the Central Nervous System
Prita R. Asih et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease
Natalia Szalaj et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)
Current and Future Treatments in Alzheimer Disease: An Update
Konstantina G. Yiannopoulou et al.
JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE (2020)
Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease
Piyoosh Sharma et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer's disease
Karolina Pierzynowska et al.
NEUROPHARMACOLOGY (2019)
Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents
Catarina Oliveira et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Developments with multi-target drugs for Alzheimer's disease: an overview of the current discovery approaches
Juan F. Gonzalez et al.
EXPERT OPINION ON DRUG DISCOVERY (2019)
Alzheimer's disease: pathogenesis, diagnostics, and therapeutics
Sneham Tiwari et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)
Novel chromanone-dithiocarbamate hybrids as multifunctional AChE inhibitors with β-amyloid anti-aggregation properties for the treatment of Alzheimer's disease
Neng Jiang et al.
BIOORGANIC CHEMISTRY (2019)
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease
Ping Bai et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Multi-target design strategies for the improved treatment of Alzheimer's disease
Pengfei Zhang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Low-dose ladostigil for mild cognitive impairment A phase 2 placebo-controlled clinical trial
Lon S. Schneider et al.
NEUROLOGY (2019)
Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
Anne-Laure Hemonnot et al.
FRONTIERS IN AGING NEUROSCIENCE (2019)
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease
Zhipei Sang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo
Matthias Scheiner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Potent and highly selective dual-targeting monoamine oxidase-B inhibitors: Fluorinated chalcones of morpholine versus imidazole
Bijo Mathew et al.
ARCHIV DER PHARMAZIE (2019)
The involvement of microglia in Alzheimer's disease: a new dog in the fight
Zachery Moore et al.
BRITISH JOURNAL OF PHARMACOLOGY (2019)
Tranilast Treatment Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through the Inhibition of Inflammatory Responses Mediated by NF-κB and PPARs
Yue Zhuo et al.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2019)
Alzheimer's disease
C. A. Lane et al.
EUROPEAN JOURNAL OF NEUROLOGY (2018)
Dementia risk and prevention by targeting modifiable vascular risk factors
Sana Tariq et al.
JOURNAL OF NEUROCHEMISTRY (2018)
Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease
Anna Wieckowska et al.
ACS CHEMICAL NEUROSCIENCE (2018)
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
Wenwen Liu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2018)
Design and synthesis of donepezil analogues as dual AChE and BACE-1 inhibitors
Moustafa T. Gabr et al.
BIOORGANIC CHEMISTRY (2018)
Soy isoflavone genistein attenuates lipopolysaccharide-induced cognitive impairments in the rat via exerting anti-oxidative and anti-inflammatory effects
Seyed-Mohamad-Sadegh Mirahmadi et al.
CYTOKINE (2018)
Tranilast directly targets NLRP3 to treat inflammasome-driven diseases
Yi Huang et al.
EMBO MOLECULAR MEDICINE (2018)
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease
Yi-xiang Xu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Memantine for the Treatment of Dementia: A Review on its Current and Future Applications
Jaume Folch et al.
JOURNAL OF ALZHEIMERS DISEASE (2018)
A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease
Sara Mostafavi et al.
NATURE NEUROSCIENCE (2018)
Tau-targeting therapies for Alzheimer disease
Erin E. Congdon et al.
NATURE REVIEWS NEUROLOGY (2018)
Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease
Ji Woong Lim et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease
Qi Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Alzheimer's disease: The right drug, the right time Lessons from failed clinical trials can improve the development of Alzheimer's disease-modifying therapies
Todd E. Golde et al.
SCIENCE (2018)
Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients
Nan Zhang et al.
CLINICAL INTERVENTIONS IN AGING (2018)
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
Fei Mao et al.
ACS CHEMICAL NEUROSCIENCE (2018)
An update on the safety of current therapies for Alzheimer's disease: focus on rivastigmine
Rita Khoury et al.
THERAPEUTIC ADVANCES IN DRUG SAFETY (2018)
Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation
Sonia Villapol
CELLULAR AND MOLECULAR NEUROBIOLOGY (2018)
Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward
David Hsu et al.
CURRENT ALZHEIMER RESEARCH (2017)
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
Jakub Jerabek et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment
Julien Lalut et al.
FUTURE MEDICINAL CHEMISTRY (2017)
Therapeutics of Neurotransmitters in Alzheimer's Disease
Ramesh Kandimalla et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Role of Glutamate and NMDA Receptors in Alzheimer's Disease
Rui Wang et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease
Eric Tonnies et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis
Jurema Schmidt et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Stop Alzheimer's before it starts
Eric McDade et al.
NATURE (2017)
Opportunities and challenges in phenotypic drug discovery: an industry perspective
John G. Moffat et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
A novel Alzheimer's disease drug candidate targeting inflammation and fatty acid metabolism
Daniel Daugherty et al.
ALZHEIMERS RESEARCH & THERAPY (2017)
Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson's disease dementia
Nagaendran Kandiah et al.
CLINICAL INTERVENTIONS IN AGING (2017)
Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors
Sayad Kocahan et al.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE (2017)
Exploration of multi-target potential of chromen-4-one based compounds in Alzheimer's disease: Design, synthesis and biological evaluations
Manjinder Singh et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2017)
Design, synthesis and biological evaluation of dual acetylcholinesterase and phosphodiesterase 5A inhibitors in treatment for Alzheimer's disease
Li-yun Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease
Orly Weinreb et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease
Elena Simoni et al.
CHEMMEDCHEM (2016)
Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation
Emiliano Pena-Altamira et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2016)
Cardiovascular effects of cyclooxygenase-2 inhibitors: a mechanistic and clinical perspective
Carlo Patrono
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2016)
Drug treatments in Alzheimer's disease
Robert Briggs et al.
CLINICAL MEDICINE (2016)
Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety
Samaneh Ghanei-Nasab et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors
Arwa Hammuda et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation
Anna Wieckowska et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Clearing Amyloid-beta through PPAR gamma/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer's Disease
Vicent Bonet-Costa et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
Mohamed Benchekroun et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents
Xiaokang Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond
Elise Cuyvers et al.
LANCET NEUROLOGY (2016)
Dysfunction of NMDA receptors in Alzheimer's disease
Yan Zhang et al.
NEUROLOGICAL SCIENCES (2016)
FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease mode
Tae-In Kam et al.
ELIFE (2016)
CB2 Cannabinoid Receptor As Potential Target against Alzheimer's Disease
Ester Aso et al.
FRONTIERS IN NEUROSCIENCE (2016)
Serotonin: A New Hope in Alzheimer's Disease?
Sylvie Claeysen et al.
ACS CHEMICAL NEUROSCIENCE (2015)
(-)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-β aggregation with high antioxidant potency for Alzheimer's therapy
Shaobing Cheng et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease
Shishun Xie et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT1A and 5-HT7 receptor ligands
Maria N. Modica et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core
Prasanna Sivaprakasam et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
A Novel Once-Daily Fixed-Dose Combination of Memantine Extended Release and Donepezil for the Treatment of Moderate to Severe Alzheimer's Disease: Two Phase I Studies in Healthy Volunteers
Ramesh Boinpally et al.
CLINICAL DRUG INVESTIGATION (2015)
New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease
Xiao-Ting Luo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease
Zhiren Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Ferulic Acid and Alzheimer's Disease: Promises and Pitfalls
Seyed Fazel Nabavi et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2015)
In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA
I. Suridjan et al.
MOLECULAR PSYCHIATRY (2015)
2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors
Lesetja J. Legoabe et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2015)
Cumulative, additive benefits of memantine-donepezil combination over component monotherapies in moderate to severe Alzheimer's dementia: a pooled area under the curve analysis
Alireza Atri et al.
ALZHEIMERS RESEARCH & THERAPY (2015)
The Possible Mechanism of Advanced Glycation End Products (AGEs) for Alzheimer's Disease
Shun-Yao Ko et al.
PLOS ONE (2015)
Curcumin, a component of golden spice: From bedside to bench and back
Sandeo Prasad et al.
BIOTECHNOLOGY ADVANCES (2014)
Multi-target approach for natural products in inflammation
Andreas Koeberle et al.
DRUG DISCOVERY TODAY (2014)
Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease
Pedro Gonzalez-Naranjo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents
Elisabet Viayna et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Polypharmacology: Challenges and Opportunities in Drug Discovery
Andrew Anighoro et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Genistein induces apoptosis and autophagy in human breast MCF-7 cells by modulating the expression of proapoptotic factors and oxidative stress enzymes
R. F. Prietsch et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2014)
Advanced Glycation End Products and Diabetic Complications
Varun Parkash Singh et al.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2014)
Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer's disease (Review)
Zhiyou Cai
MOLECULAR MEDICINE REPORTS (2014)
Discovery and Development of Small Molecule SHIP Phosphatase Modulators
Dennis R. Viernes et al.
MEDICINAL RESEARCH REVIEWS (2014)
New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol
Fei Mao et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2014)
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment
Cedric Lecoutey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Tau protein kinases: Involvement in Alzheimer's disease
Ludovic Martin et al.
AGEING RESEARCH REVIEWS (2013)
Can we prevent Alzheimer's disease? Secondary prevention trials in Alzheimer's disease
Maria C. Carrillo et al.
ALZHEIMERS & DEMENTIA (2013)
The Effect of Genistein on the Content and Activity of α- and β-Secretase and Protein Kinase C in Aβ-Injured Hippocampal Neurons
Weiliang Liao et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2013)
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease
Tae-In Kam et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Propargylamine-derived multitarget-directed ligands: fighting Alzheimer's disease with monoamine oxidase inhibitors
Irene Bolea et al.
JOURNAL OF NEURAL TRANSMISSION (2013)
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
Clifford R. Jack et al.
LANCET NEUROLOGY (2013)
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
Pierre Paoletti et al.
NATURE REVIEWS NEUROSCIENCE (2013)
Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD
Carolina Garcia-Barroso et al.
NEUROPHARMACOLOGY (2013)
Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease
Ana Garcia-Osta et al.
ACS CHEMICAL NEUROSCIENCE (2012)
A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease
Preet Anand et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease
Elena Simoni et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: Discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities
Wenhai Huang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Sustained Effects of Once-Daily Memantine Treatment on Cognition and Functional Communication Skills in Patients with Moderate to Severe Alzheimer's Disease: Results of a 16-Week Open-Label Trial
Joerg B. Schulz et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)
J. Jean Cui et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Revisiting the cholinergic in the development of Alzheimer's disease
Laura A. Craig et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2011)
Synapses, NMDA receptor activity and neuronal A beta production in Alzheimer's disease
Karim Bordji et al.
REVIEWS IN THE NEUROSCIENCES (2011)
Galantamine treatment in Alzheimer's disease: response and long-term outcome in a routine clinical setting
Åsa Wallin et al.
Neuropsychiatric Disease and Treatment (2011)
APP processing in Alzheimer's disease
Yun-Wu Zhang et al.
MOLECULAR BRAIN (2011)
The use of multi-target drugs in the treatment of neurodegenerative diseases
Cornelis J Van der Schyf
Expert Review of Clinical Pharmacology (2011)
CB2: a cannabinoid receptor with an identity crisis
Brady K. Atwood et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Effectiveness and Tolerability of High-Dose (23 mg/d) Versus Standard-Dose (10 mg/d) Donepezil in Moderate to Severe Alzheimer's Disease: A 24-Week, Randomized, Double-Blind Study
Martin R. Farlow et al.
CLINICAL THERAPEUTICS (2010)
Microglia and Inflammation in Alzheimer's Disease
Shweta Mandrekar-Colucci et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2010)
Isoflavone effect on gene expression profile and biomarkers of inflammation
M. Blay et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2010)
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
John C. O'Leary et al.
MOLECULAR NEURODEGENERATION (2010)
Rasagiline: A novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity
Orly Weinreb et al.
PROGRESS IN NEUROBIOLOGY (2010)
Synthesis, Molecular Modeling, and Selective Inhibitory Activity against Human Monoamine Oxidases of 3-Carboxamido-7-Substituted Coumarins
Franco Chimenti et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Predicting new molecular targets for known drugs
Michael J. Keiser et al.
NATURE (2009)
Multifunctional Drugs As Neurotherapeutics
Cornelis J. Van der Schyf et al.
NEUROTHERAPEUTICS (2009)
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling
Scott D. Bembenek et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
The role of peroxisome proliferator-activated receptor-gamma (PPAR gamma) in Alzheimer's disease
Qingguang Jiang et al.
CNS DRUGS (2008)
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors
F. Leveille et al.
FASEB JOURNAL (2008)
Inhibition of acetylcholinesterase, β-amyloid aggregation, and NMDA receptors in Alzheimer's disease:: A promising direction for the multi-target-directed ligands gold rush
Michela Rosini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease
Magdolna Paskaski et al.
NEUROCHEMISTRY INTERNATIONAL (2008)
Inhibition of lipoxygenase by soy isoflavones: Evidence of isoflavones as redox inhibitors
H. G. Mahesha et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
Chemogenomic approaches to rational drug design
D. Rognan
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine - Preparation of S-substituted thiosuccinic acid esters
Thomas J. Schmidt et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Rivastigmine in the treatment of Alzheimer's disease: an update
Maria Luisa Onor et al.
CLINICAL INTERVENTIONS IN AGING (2007)
Recent developments in chotinesterases inhibitors for Alzheimer's disease treatment
Anna Musial et al.
CURRENT MEDICINAL CHEMISTRY (2007)
Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness
MBH Youdim et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
The physicochemical challenges of designing multiple ligands
Richard Morphy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Soya isoflavones suppress phorbol 12-myristate 13-acetate-induced COX-2 expression in MCF-7 cells
Tak Yi Lau et al.
BRITISH JOURNAL OF NUTRITION (2006)
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen
N Thavichachart et al.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2006)
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors
Ana Castro et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Memantine - A review of its use in Alzheimer's disease
Dean M. Robinson et al.
DRUGS (2006)
Designed multiple ligands. An emerging drug discovery paradigm
R Morphy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
Jared Ehrhart et al.
JOURNAL OF NEUROINFLAMMATION (2005)
Rational approach to discover multipotent anti-Alzheimer drugs
M Rosini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Comparison between daidzein and genistein antioxidant activity in primary and cancer lymphocytes
P Foti et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
A 12-month study of the efficacy of rivastigmine in patients with advanced moderate Alzheimer's disease
Y Karaman et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2005)
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil - A randomized controlled trial
PN Tariot et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)
A mitochondrial cascade hypthesis for sporadic Alzheimer's disease
RH Swerdlow et al.
MEDICAL HYPOTHESES (2004)
Efficacy and tolerability of donepezil in vascular dementia -: Positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial
S Black et al.
STROKE (2003)
The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: Recent challenges and their implications for novel drug development
AV Terry et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
CJ Phiel et al.
NATURE (2003)