期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 12, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/jpm12111836
关键词
personalized medicine; precision medicine; pharmacogenetic testing; public acceptance; socio-demographic characteristics; health-related behaviors; subjective health; perceived genetic risk; personality factors
Majorities are willing to accept genetic testing for personalized treatment, with higher rates in younger men and those with higher income. Additionally, ex-smokers, obese individuals, those with perceived genetic risk, and those with certain personality traits show more interest.
Studies from various countries have shown that majorities would accept genetic testing for personalization of treatment, but little is known about differences among population subgroups. The present study investigated whether readiness to accept a hypothetical cost-free offer of genetic testing to personalize treatment depends on socio-demographic characteristics, health-related vulnerabilities, personal dispositions, and prior awareness about personalized medicine. The study was based on a cross-sectional survey design. Out of a representative initial sample of 50-80-year-old Danish citizens (n = 15,072), n = 6807 returned a fully answered web-based questionnaire. Socio-demographic data were added from a national registry. Data were analyzed by multivariable logistic regression. A large majority of respondents (78.3%) expressed their readiness to be tested. Rates were higher in men, younger persons, and those with higher income. Additionally, ex-smokers and obese persons as well as those less satisfied with their health and respondents who perceived a personal genetic risk were more interested, as were those with higher internal health control, higher extraversion, higher emotional stability, and those who had not heard about this option before. Further research should investigate the specific concerns among population subgroups which need being addressed by systematic communication efforts in a clinical but also a broader public health context.
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