4.7 Review

Cytokine Pathways in Cardiac Dysfunction following Burn Injury and Changes in Genome Expression

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Innate Immune System Response to Burn Damage-Focus on Cytokine Alteration

Olga Sierawska et al.

Summary: Burns are traumatic events that increase morbidity and mortality among patients. The swelling and redness at the burn site indicate inflammation, which is important for wound healing and immune system stimulation. Inflammation can lead to infections and negative consequences for the body.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Critical Care Medicine

Early Transcriptomic Response to Burn Injury: Severe Burns Are Associated With Immune Pathway Shutdown

John W. Keyloun et al.

Summary: Burn injury induces an early proinflammatory immune response followed by shutdown of immune pathways. This study aims to characterize the blood transcriptome after burn injury. Analysis of patient blood samples revealed differential gene expression and enrichment of immune/inflammatory pathways based on burn injury severity.

JOURNAL OF BURN CARE & RESEARCH (2022)

Article Health Care Sciences & Services

Regulation of Key Immune-Related Genes in the Heart Following Burn Injury

Jake J. Wen et al.

Summary: This study identified differentially expressed genes related to the TLR signaling pathway after burn injury and confirmed the important role of burn-induced cytokine cascade in burn-induced heart dysfunction.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Surgery

Nuclear Factor Erythroid 2-Related Factor 2 Activation and Burn-Induced Cardiac Dysfunction

Jake J. Wen et al.

Summary: Burn injury can cause cardiac dysfunction by interrupting the antioxidant-response element pathway in cardiac mitochondria. This study showed that Nrf2 deficiency worsens burn-induced cardiac dysfunction, while Nrf2 activation with Olti improves cardiac function and offers a promising therapeutic strategy.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2022)

Article Medical Laboratory Technology

Cytokine signature of inflammation mediated by autoreactive Th-cells, in calf muscle of claudicating patients with Fontaine stage II peripheral artery disease

George P. Casale et al.

Summary: In this study, a cytokine profile of autoimmune inflammation was identified in the calf muscles of a significant proportion of claudicating PAD patients, associated with decreased limb function. Additionally, a second independent profile consistent with increased inflammaging was observed in all PAD patients. Serum cytokines were not indicative of muscle cytokine expression.

TRANSLATIONAL RESEARCH (2021)

Review Biochemistry & Molecular Biology

Trauma, a Matter of the Heart-Molecular Mechanism of Post-Traumatic Cardiac Dysfunction

Birte Weber et al.

Summary: Trauma is a leading cause of mortality in young populations globally, and cardiac damage after multiple trauma can lead to poor outcomes. Systemic measurement of cardiac troponins can determine survival rates, injury severity, and catecholamine consumption in trauma patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Surgery

Effect of Mitochondrial Antioxidant (Mito-TEMPO) on Burn-Induced Cardiac Dysfunction

Jake J. Wen et al.

Summary: The study demonstrated that the mitochondrial-specific antioxidant Mito-TEMPO partially improved burn-induced cardiac dysfunction by protecting cardiac mitochondrial function through multiple signaling pathways.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2021)

Review Immunology

Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

Shireen Mohammad et al.

Summary: Diet-induced metabolic endotoxemia can lead to chronic inflammatory conditions due to changes in gut permeability, causing toxins to enter the bloodstream and triggering systemic inflammation. verschiedenen pro-inflammatory cytokines, resulting in chronic low-grade inflammation.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

Dan-in Jang et al.

Summary: TNF-α was originally identified as a factor causing tumor necrosis but has also been recognized as a pathological component of autoimmune diseases. Its signaling pathways play important roles in cellular responses, and inappropriate activation can lead to chronic inflammation and autoimmune diseases. TNF-α inhibitors have been developed as effective therapeutic tools for various autoimmune diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Cell Biology

The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies

Hongyang Xu et al.

Summary: SERCA pump plays a crucial role in maintaining cellular calcium homeostasis and its function is closely linked to muscle health and function. Pathological conditions can impair SERCA activity, leading to muscle atrophy and weakness. Therefore, targeting SERCA activity has emerged as a potential therapeutic approach for muscle pathologies.

SKELETAL MUSCLE (2021)

Article Cardiac & Cardiovascular Systems

Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction

Kaspar Broch et al.

Summary: The study showed that tocilizumab, an interleukin-6 receptor inhibitor, increased myocardial salvage in patients with acute STEMI, reduced microvascular obstruction, but did not significantly decrease final infarct size.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Review Biochemistry & Molecular Biology

Role of β-Adrenergic Receptors and Estrogen in Cardiac Repair after Myocardial Infarction: An Overview

Paola Matarrese et al.

Summary: This article discusses the crucial role of cardiac repair after acute myocardial infarction, particularly focusing on the involvement of catecholamines and estrogen in regulating the inflammatory response and their impact on infarct size and survival rates.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway

Jake J. Wen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Cardiac & Cardiovascular Systems

Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure

Anis Hanna et al.

CARDIOVASCULAR DRUGS AND THERAPY (2020)

Article Critical Care Medicine

CLINICAL IMPORTANCE OF A CYTOKINE NETWORK IN MAJOR BURNS

Hiroshi Matsuura et al.

Review Immunology

Structural Basis of IL-1 Family Cytokine Signaling

James K. Fields et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Genome-wide comparisons of gene expression in adult versus elderly burn patients

Stephanie C. Dreckmann et al.

PLOS ONE (2019)

Review Cardiac & Cardiovascular Systems

Tumor Necrosis Factor- in Heart Failure: an Updated Review

Sarah M. Schumacher et al.

CURRENT CARDIOLOGY REPORTS (2018)

Article Public, Environmental & Occupational Health

Tnf-α/IL-10 Ratio Correlates with Burn Severity and May Serve as a Risk Predictor of Increased Susceptibility to Infections

Amy Tsurumi et al.

FRONTIERS IN PUBLIC HEALTH (2016)

Article Medicine, General & Internal

Pathophysiologic Response to Burns in the Elderly

Marc G. Jeschke et al.

EBIOMEDICINE (2015)

Article Surgery

Toll like receptors gene expression of human keratinocytes cultured of severe burn injury

Sarita Mac Cornick et al.

ACTA CIRURGICA BRASILEIRA (2014)

Article Cell Biology

Interleukin-1β induces a reversible cardiomyopathy in the mouse

Benjamin W. Van Tassell et al.

INFLAMMATION RESEARCH (2013)

Article Critical Care Medicine

Burn-Induced Cardiac Dysfunction Increases Length of Stay in Pediatric Burn Patients

Taylor S. Howard et al.

JOURNAL OF BURN CARE & RESEARCH (2013)

Review Biochemistry & Molecular Biology

HMGB1 and leukocyte migration during trauma and sterile inflammation

Emilie Venereau et al.

MOLECULAR IMMUNOLOGY (2013)

Article Biotechnology & Applied Microbiology

Systemic Inflammation Is Associated with Differential Gene Expression and Airway Neutrophilia in Asthma

Juan-juan Fu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Recombinant Human Interleukin-1 Receptor Antagonist Provides Cardioprotection During Myocardial Ischemia Reperfusion in the Mouse

Stefano Toldo et al.

CARDIOVASCULAR DRUGS AND THERAPY (2012)

Article Cell Biology

Aging is associated with circulating cytokine dysregulation

Lorena Alvarez-Rodriguez et al.

CELLULAR IMMUNOLOGY (2012)

Article Multidisciplinary Sciences

Impact of an Interleukin-1 Receptor Antagonist and Erythropoietin on Experimental Myocardial Ischemia/Reperfusion Injury

Christina Grothusen et al.

SCIENTIFIC WORLD JOURNAL (2012)

Review Immunology

Gender Specific Differences in the Immune Response to Infection

Erin E. McClelland et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2011)

Article Critical Care Medicine

Changes in Cardiac Physiology After Severe Burn Injury

Felicia N. Williams et al.

JOURNAL OF BURN CARE & RESEARCH (2011)

Article Immunology

A genomic storm in critically injured humans

Wenzhong Xiao et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Review Dermatology

The biology of burn injury

Lars H. Evers et al.

EXPERIMENTAL DERMATOLOGY (2010)

Review Cell Biology

Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart

Soban Umar et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2010)

Article Cardiac & Cardiovascular Systems

Role of interleukin-6 in cardiac inflammation and dysfunction after burn complicated by sepsis

Hongchao Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Article Physiology

Effects of burn injury on myocardial signaling and cytokine secretion: possible role of PKC

Jing Tan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)

Article Critical Care Medicine

Reversible cardiomyopathy after severe burn injury

Grace Z. Mak et al.

JOURNAL OF BURN CARE & RESEARCH (2006)

Article Critical Care Medicine

Cytokine expression profile over time in severely burned pediatric patients

Celeste C. Finnerty et al.

Article Multidisciplinary Sciences

A network-based analysis of systemic inflammation in humans

SE Calvano et al.

NATURE (2005)

Article Biochemistry & Molecular Biology

PKC-α regulates cardiac contractility and propensity toward heart failure

JC Braz et al.

NATURE MEDICINE (2004)

Review Cardiac & Cardiovascular Systems

Cytokine-induced modulation of cardiac function

SD Prabhu

CIRCULATION RESEARCH (2004)

Article Physiology

Burn trauma alters calcium transporter protein expression in the heart

C Ballard-Croft et al.

JOURNAL OF APPLIED PHYSIOLOGY (2004)

Article Cardiac & Cardiovascular Systems

Role of p38 mitogen-activated protein kinase in cardiac myocyte secretion of the inflammatory cytokine TNF-α

C Ballard-Croft et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2001)

Review Critical Care Medicine

Effect of gender and sex hormones on immune responses following shock

MK Angele et al.

Article Cardiac & Cardiovascular Systems

Leukemia inhibitory factor and interleukin-6 downregulate sarcoplasmic reticulum Ca2+ ATPase (SERCA2) in cardiac myocytes

S Villegas et al.

BASIC RESEARCH IN CARDIOLOGY (2000)