4.7 Article

Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS

Ilena Vincenti et al.

Summary: The study reveals that tissue-resident memory T cells (T-RM) may initiate CNS inflammation and immunopathology in chronic inflammatory diseases of the central nervous system (CNS), independent of circulating CD8(+) T cells. In the absence of CD4(+) T cells, CD8(+) T cells fail to expand and differentiate into terminal effectors. This sheds light on why inflammatory processes may evade current immunomodulatory treatments in chronic autoimmune CNS conditions.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Article Cell Biology

Tissue-resident CD8+ T cells drive compartmentalized and chronic autoimmune damage against CNS neurons

David Frieser et al.

Summary: This study reveals the important role of tissue-resident memory T cells, particularly pathogenic CD8(+) T cells, in chronic autoimmune diseases of the central nervous system. These cells are crucial for sustaining chronic inflammation and progressive loss of neurons, and they exhibit phenotypic and functional heterogeneity. The presence and functional output of tissue-resident CD8(+) T cells depend critically on CD4(+) T cells. Therefore, therapies targeting this compartmentalized autoreactive T cell subset may be effective for treating CNS autoimmune diseases.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Article Cell Biology

Proinflammatory CD20+ T cells contribute to CNS-directed autoimmunity

Jasmin Ochs et al.

Summary: The study found that CD20(+) T cells acquire CD20 from B cells via trogocytosis and interaction with B cells leads to activation, indicating high pathogenic potential. CD20(+) T cells increase during experimental autoimmune encephalomyelitis (EAE), and eliminating CD20(+) T cells can effectively ameliorate EAE.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Review Immunology

T-cell surveillance of the human brain in health and multiple sclerosis

Joost Smolders et al.

Summary: The role of T cells in the brain has been underestimated due to the compartmentalized organization. However, recent studies on patients with early multiple sclerosis have shown that T cells play a crucial role in the pathology of the disease.

SEMINARS IN IMMUNOPATHOLOGY (2022)

Article Cell Biology

Distinct Effector Programs of Brain-Homing CD8+ T Cells in Multiple Sclerosis

Steven C. Koetzier et al.

Summary: The effector programs of CD8(+) memory T cells in multiple sclerosis (MS) are influenced by transcription factors RUNX3, EOMES, and T-bet. This study found that the frequencies of RUNX3- and EOMES-expressing CD8(+) memory T cells were reduced in the blood of MS patients, but not in MS patients treated with natalizumab. CD8(+) memory T cells that co-express RUNX3 and EOMES and do not express T-bet were enriched in the MS cerebrospinal fluid and associated with brain residency-associated markers. These findings suggest that the co-expression of RUNX3 and EOMES defines CD8(+) memory T cells with a pre-existing brain residency-associated phenotype in MS.
Article Immunology

Tissue-resident memory CD8(+) T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

John T. Crowl et al.

Summary: This study investigates the diversity of gene expression and genome accessibility in mouse CD8(+) T-RM cells in different tissues, and identifies molecules critical for the generation of CD8(+) T-RM cells in response to acute viral infection. The research reveals both common and tissue-specific transcriptional and epigenetic signatures in T-RM cells from different organs. T-RM cells in the intestine and salivary glands express TGF-beta-induced genes and are maintained by ongoing TGF-beta signaling, while those in the fat, kidney, and liver do not. Furthermore, the study identifies the transcriptional repressor Hic1 as a critical regulator of T-RM cell differentiation in the small intestine, and shows that Hic1 overexpression enhances T-RM cell differentiation and protection from infection.

NATURE IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

Functional characterization of the dural sinuses as a neuroimmune interface

Justin Rustenhoven et al.

Summary: The CNS-derived antigens in the cerebrospinal fluid accumulate around the dural sinuses and are captured by local antigen-presenting cells to be presented to T cells, promoting tissue resident phenotypes and effector functions within the dural meninges. The dural sinuses play a critical role as a neuroimmune interface, facilitating the surveillance of brain antigens under steady-state conditions.
Article Clinical Neurology

CSF Levels of CXCL12 and Osteopontin as Early Markers of Primary Progressive Multiple Sclerosis

Damiano Marastoni et al.

Summary: The study evaluated the extent of intrathecal inflammation in patients with PPMS and RRMS at diagnosis, identifying higher levels of CXCL12 and osteopontin in PPMS, and increased IL-10 levels in RRMS. Elevated CXCL12 levels were associated with gray matter lesion burden, indicating a potential role of brain innate immunity and glial activity in MS progression. This suggests that specific CSF protein profiles could help differentiate between PPMS and RRMS, and these molecules may serve as useful candidate markers for understanding and treating progressive MS.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Article Multidisciplinary Sciences

A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis

Martina Absinta et al.

Summary: Through MRI-guided single-nucleus RNA sequencing, a diversity of glial and immune cells at the edge of demyelinated white matter lesions in multiple sclerosis (MS) have been identified, along with the definition of inflamed glial cell phenotypes in MS. The overlap of the transcriptional profile of microglia inflamed in MS with that in other neurodegenerative diseases suggests common mechanisms between primary and secondary neurodegeneration that could benefit from similar therapeutic approaches. The critical role of complement component 1q (C1q) in the activation of microglia inflamed in MS has been identified and potential therapeutic avenues, such as C1q inhibition, have been suggested for addressing chronic white matter inflammation.

NATURE (2021)

Review Clinical Neurology

Review of Phase III Clinical Trials Outcomes in Patients with Secondary Progressive Multiple Sclerosis

Matthew McAdams et al.

Summary: Based on the review of clinical trials on SPMS patients since 1990, time to confirmed disability progression and changes in MSFC are common primary outcome measures, while PROs and MRI measures are frequently used as secondary outcome measures. Successful trials may be related to patient selection, suggesting the importance of carefully selecting appropriate outcome measures for future SPMS research.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Article Neurosciences

The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF

Christine Harrer et al.

Summary: The study found a strong correlation between intrathecal CXCL13 elevations and CXCR5+CD4 T cell frequencies in CSF, suggesting recruitment of possible professional B cell helpers to the inflamed CNS, which is important for infection control, chronic inflammation, and CNS autoimmunity.

FLUIDS AND BARRIERS OF THE CNS (2021)

Review Clinical Neurology

Perivascular tissue resident memory T cells as therapeutic target in multiple sclerosis

Joost Smolders et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2020)

Review Clinical Neurology

Remyelination in multiple sclerosis: from basic science to clinical translation

Catherine Lubetzki et al.

LANCET NEUROLOGY (2020)

Article Immunology

Physiology and pathology of T-cell aging

Nagahiro Minato et al.

INTERNATIONAL IMMUNOLOGY (2020)

Article Immunology

Precursor exhausted T cells: key to successful immunotherapy?

Axel Kallies et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

Takahiro Masuda et al.

NATURE (2019)

Article Immunology

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

Laura M. McLane et al.

Annual Review of Immunology (2019)

Review Immunology

Location, location, location: Tissue resident memory T cells in mice and humans

Peter A. Szabo et al.

SCIENCE IMMUNOLOGY (2019)

Article Medicine, Research & Experimental

Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis

Eduardo Beltran et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Biotechnology & Applied Microbiology

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Daehwan Kim et al.

NATURE BIOTECHNOLOGY (2019)

Article Multidisciplinary Sciences

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolas A. Patsopoulos et al.

SCIENCE (2019)

Article Clinical Neurology

Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis

Marina R. von Essen et al.

Article Immunology

Local Antigen Encounter Is Essential for Establishing Persistent CD8+ T-Cell Memory in the CNS

Amalie S. Scholler et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Biochemical Research Methods

fastp: an ultra-fast all-in-one FASTQ preprocessor

Shifu Chen et al.

BIOINFORMATICS (2018)

Review Neurosciences

CNS infection and immune privilege

John V. Forrester et al.

NATURE REVIEWS NEUROSCIENCE (2018)

Article Multidisciplinary Sciences

Tissue-resident memory T cells populate the human brain

Joost Smolders et al.

NATURE COMMUNICATIONS (2018)

Article Neurosciences

Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

Mark R. Mizee et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

QuPath: Open source software for digital pathology image analysis

Peter Bankhead et al.

SCIENTIFIC REPORTS (2017)

Review Immunology

Understanding the Role of T Cells in CNS Homeostasis

Erik Ellwardt et al.

TRENDS IN IMMUNOLOGY (2016)

Review Immunology

Tissue-resident memory T cells: local specialists in immune defence

Scott N. Mueller et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Immunology

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

Aleksanteri Aspelund et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Article Biochemical Research Methods

Orchestrating high-throughput genomic analysis with Bioconductor

Wolfgang Huber et al.

NATURE METHODS (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemical Research Methods

HTSeq-a Python framework to work with high-throughput sequencing data

Simon Anders et al.

BIOINFORMATICS (2015)

Review Immunology

Molecular and cellular insights into T cell exhaustion

E. John Wherry et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Article Immunology

Rituximab Efficiently Depletes Increased CD20-Expressing T Cells in Multiple Sclerosis Patients

Arumugam Palanichamy et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Biotechnology & Applied Microbiology

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

Charity W. Law et al.

GENOME BIOLOGY (2014)

Article Clinical Neurology

Characteristics of differentiated CD8+ and CD4+ T cells present in the human brain

Joost Smolders et al.

ACTA NEUROPATHOLOGICA (2013)

Article Biochemistry & Molecular Biology

Camera: a competitive gene set test accounting for inter-gene correlation

Di Wu et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Medical Laboratory Technology

Central Memory CD4(+) T Cells Dominate the Normal Cerebrospinal Fluid

Marieke T. de Graaf et al.

CYTOMETRY PART B-CLINICAL CYTOMETRY (2011)

Article Immunology

Intracellular osteopontin (iOPN) and immunity

Makoto Inoue et al.

IMMUNOLOGIC RESEARCH (2011)

Article Multidisciplinary Sciences

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

Linda M. Wakim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biotechnology & Applied Microbiology

A scaling normalization method for differential expression analysis of RNA-seq data

Mark D. Robinson et al.

GENOME BIOLOGY (2010)

Article Biochemical Research Methods

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

Steffen Durinck et al.

NATURE PROTOCOLS (2009)

Article Clinical Neurology

Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions

Nathalie Koning et al.

ANNALS OF NEUROLOGY (2007)

Article Multidisciplinary Sciences

T-bet-dependent expression of osteopontin contributes to T cell polarization

ML Shinohara et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Immunology

Osteopontin gene haplotypes correlate with multiple sclerosis development and progression

A Chiocchetti et al.

JOURNAL OF NEUROIMMUNOLOGY (2005)

Article Immunology

Plasma osteopontin levels in multiple sclerosis

M Comabella et al.

JOURNAL OF NEUROIMMUNOLOGY (2005)

Review Clinical Neurology

Magnetic resonance imaging as a tool to examine the neuropathology of multiple sclerosis

L Bö et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2004)

Article Multidisciplinary Sciences

Human cerebrospinal fluid central memory CD4+ T cells:: Evidence for trafficking through choroid plexus and meninges via P-selectin

P Kivisäkk et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

Article Medicine, Research & Experimental

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

DT Denhardt et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)